A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi
Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/8/4594 |
| _version_ | 1817996076688343040 |
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| author | Yan-Ting Wang Ya-Rong Xue Chang-Hong Liu |
| author_facet | Yan-Ting Wang Ya-Rong Xue Chang-Hong Liu |
| author_sort | Yan-Ting Wang |
| collection | DOAJ |
| description | Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development. |
| first_indexed | 2024-04-14T02:16:45Z |
| format | Article |
| id | doaj.art-a283679531ab40c49217698ce1e032b2 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T02:16:45Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a283679531ab40c49217698ce1e032b22022-12-22T02:18:09ZengMDPI AGMarine Drugs1660-33972015-07-011384594461610.3390/md13084594md13084594A Brief Review of Bioactive Metabolites Derived from Deep-Sea FungiYan-Ting Wang0Ya-Rong Xue1Chang-Hong Liu2State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing UniversityDeep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.http://www.mdpi.com/1660-3397/13/8/4594deep-sea fungibioactive compoundsanticancerantimicrobialantiviralantifungal |
| spellingShingle | Yan-Ting Wang Ya-Rong Xue Chang-Hong Liu A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi Marine Drugs deep-sea fungi bioactive compounds anticancer antimicrobial antiviral antifungal |
| title | A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi |
| title_full | A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi |
| title_fullStr | A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi |
| title_full_unstemmed | A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi |
| title_short | A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi |
| title_sort | brief review of bioactive metabolites derived from deep sea fungi |
| topic | deep-sea fungi bioactive compounds anticancer antimicrobial antiviral antifungal |
| url | http://www.mdpi.com/1660-3397/13/8/4594 |
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