Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells
Mitochondrial ion channels are emerging oncological targets, as modulation of these ion-transporting proteins may impact on mitochondrial membrane potential, efficiency of oxidative phosphorylation and reactive oxygen production. In turn, these factors affect the release of cytochrome c, which is th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/6/761 |
| _version_ | 1797725151503056896 |
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| author | Roberta Peruzzo Ildiko Szabo |
| author_facet | Roberta Peruzzo Ildiko Szabo |
| author_sort | Roberta Peruzzo |
| collection | DOAJ |
| description | Mitochondrial ion channels are emerging oncological targets, as modulation of these ion-transporting proteins may impact on mitochondrial membrane potential, efficiency of oxidative phosphorylation and reactive oxygen production. In turn, these factors affect the release of cytochrome c, which is the point of no return during mitochondrial apoptosis. Many of the currently used chemotherapeutics induce programmed cell death causing damage to DNA and subsequent activation of p53-dependent pathways that finally leads to cytochrome c release from the mitochondrial inter-membrane space. The view is emerging, as summarized in the present review, that ion channels located in this organelle may account in several cases for the resistance that cancer cells can develop against classical chemotherapeutics, by preventing drug-induced apoptosis. Thus, pharmacological modulation of these channel activities might be beneficial to fight chemo-resistance of different types of cancer cells. |
| first_indexed | 2024-03-12T10:26:59Z |
| format | Article |
| id | doaj.art-a284e2db1e2e4b5692beda54c97d4726 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:26:59Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a284e2db1e2e4b5692beda54c97d47262023-09-02T09:38:06ZengMDPI AGCancers2072-66942019-05-0111676110.3390/cancers11060761cancers11060761Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer CellsRoberta Peruzzo0Ildiko Szabo1Department of Biology, University of Padova, 35131 Padova, ItalyDepartment of Biology, University of Padova, 35131 Padova, ItalyMitochondrial ion channels are emerging oncological targets, as modulation of these ion-transporting proteins may impact on mitochondrial membrane potential, efficiency of oxidative phosphorylation and reactive oxygen production. In turn, these factors affect the release of cytochrome c, which is the point of no return during mitochondrial apoptosis. Many of the currently used chemotherapeutics induce programmed cell death causing damage to DNA and subsequent activation of p53-dependent pathways that finally leads to cytochrome c release from the mitochondrial inter-membrane space. The view is emerging, as summarized in the present review, that ion channels located in this organelle may account in several cases for the resistance that cancer cells can develop against classical chemotherapeutics, by preventing drug-induced apoptosis. Thus, pharmacological modulation of these channel activities might be beneficial to fight chemo-resistance of different types of cancer cells.https://www.mdpi.com/2072-6694/11/6/761mitochondrial ion channelspermeabilization and cytochrome c releaseresistance to apoptosis |
| spellingShingle | Roberta Peruzzo Ildiko Szabo Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells Cancers mitochondrial ion channels permeabilization and cytochrome c release resistance to apoptosis |
| title | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
| title_full | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
| title_fullStr | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
| title_full_unstemmed | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
| title_short | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
| title_sort | contribution of mitochondrial ion channels to chemo resistance in cancer cells |
| topic | mitochondrial ion channels permeabilization and cytochrome c release resistance to apoptosis |
| url | https://www.mdpi.com/2072-6694/11/6/761 |
| work_keys_str_mv | AT robertaperuzzo contributionofmitochondrialionchannelstochemoresistanceincancercells AT ildikoszabo contributionofmitochondrialionchannelstochemoresistanceincancercells |