The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals
Abstract Background Recent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on c...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-023-01289-3 |
| _version_ | 1797864511757090816 |
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| author | Mahsa Mahmoudinezhad Sheida Khosravaniardakani Leila Saljoughi Badelou Ehsan Fayyazishishavan Houman Kahroba Mahdieh Abbasalizad Farhangi |
| author_facet | Mahsa Mahmoudinezhad Sheida Khosravaniardakani Leila Saljoughi Badelou Ehsan Fayyazishishavan Houman Kahroba Mahdieh Abbasalizad Farhangi |
| author_sort | Mahsa Mahmoudinezhad |
| collection | DOAJ |
| description | Abstract Background Recent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on cardiometabolic risk factors. Methods This cross-sectional study was carried out on 347 obese adults aged 20-50 years old in Tabriz, Iran. Healthy eating index (HEI) and Diet quality index-international (DQI-I) were evaluated by a validated semi-quantitative 147-item Food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine FADS2 gene variants. Multivariate analysis of covariance (MANCOVA) was used to identify gene-diet interactions on metabolic parameters. Results Waist circumference (WC) and serum triglyceride (TG) levels were significantly higher among carriers of TT genotype of FADS2 gene (P < 0.05). In addition, the interactions between FADS2 gene rs174583 polymorphism and DQI-I had significant effects on weight (P interaction = 0.01), fat mass (P interaction = 0.04), fat free mass (P interaction = 0.03), and Body mass index (BMI) (P interaction = 0.02); the highest level of these parameters belonged to TT carriers. Similarly, the interactions between FADS2 gene variants and HEI had significant effects on insulin (P interaction < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (P interaction < 0.001), Quantitative insulin check index (QUICKI) (P interaction = 0.001), and alpha Melanocyte stimulating hormone (α-MSH) (P interaction = 0.03). Conclusion In this study, for the first time, we reported the effects of gene-diet interactions on metabolic traits. Compliance with dietary indices (DQI-I and HEI) ameliorated the adverse effects of gene variants on metabolic risk factors, especially in heterogeneous genotypes. Further prospective cohort studies are needed to confirm these results. |
| first_indexed | 2024-04-09T22:53:04Z |
| format | Article |
| id | doaj.art-a287a2d4994b4a7fb6834f98fa4069d4 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-09T22:53:04Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-a287a2d4994b4a7fb6834f98fa4069d42023-03-22T11:33:36ZengBMCBMC Endocrine Disorders1472-68232023-02-0123111210.1186/s12902-023-01289-3The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individualsMahsa Mahmoudinezhad0Sheida Khosravaniardakani1Leila Saljoughi Badelou2Ehsan Fayyazishishavan3Houman Kahroba4Mahdieh Abbasalizad Farhangi5Molecular Medicine Research Center, Tabriz University of Medical SciencesDepartment of Epidemiology, Robert Stempel College of Public Health, Florida International UniversityDepartment of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston (UTHealth)Department of Toxicogenomics, GROW School of Oncology and Development Biology, Maastricht UniversityDrug Applied Research Center, Tabriz University of Medical SciencesAbstract Background Recent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on cardiometabolic risk factors. Methods This cross-sectional study was carried out on 347 obese adults aged 20-50 years old in Tabriz, Iran. Healthy eating index (HEI) and Diet quality index-international (DQI-I) were evaluated by a validated semi-quantitative 147-item Food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine FADS2 gene variants. Multivariate analysis of covariance (MANCOVA) was used to identify gene-diet interactions on metabolic parameters. Results Waist circumference (WC) and serum triglyceride (TG) levels were significantly higher among carriers of TT genotype of FADS2 gene (P < 0.05). In addition, the interactions between FADS2 gene rs174583 polymorphism and DQI-I had significant effects on weight (P interaction = 0.01), fat mass (P interaction = 0.04), fat free mass (P interaction = 0.03), and Body mass index (BMI) (P interaction = 0.02); the highest level of these parameters belonged to TT carriers. Similarly, the interactions between FADS2 gene variants and HEI had significant effects on insulin (P interaction < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (P interaction < 0.001), Quantitative insulin check index (QUICKI) (P interaction = 0.001), and alpha Melanocyte stimulating hormone (α-MSH) (P interaction = 0.03). Conclusion In this study, for the first time, we reported the effects of gene-diet interactions on metabolic traits. Compliance with dietary indices (DQI-I and HEI) ameliorated the adverse effects of gene variants on metabolic risk factors, especially in heterogeneous genotypes. Further prospective cohort studies are needed to confirm these results.https://doi.org/10.1186/s12902-023-01289-3Fatty acid desaturaseDiet quality index-internationalHealthy eating indexObesity |
| spellingShingle | Mahsa Mahmoudinezhad Sheida Khosravaniardakani Leila Saljoughi Badelou Ehsan Fayyazishishavan Houman Kahroba Mahdieh Abbasalizad Farhangi The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals BMC Endocrine Disorders Fatty acid desaturase Diet quality index-international Healthy eating index Obesity |
| title | The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals |
| title_full | The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals |
| title_fullStr | The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals |
| title_full_unstemmed | The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals |
| title_short | The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals |
| title_sort | integrative panel of fatty acid desaturase 2 fads2 rs174583 gene polymorphism and dietary indices dqi i and hei affects cardiovascular risk factors among obese individuals |
| topic | Fatty acid desaturase Diet quality index-international Healthy eating index Obesity |
| url | https://doi.org/10.1186/s12902-023-01289-3 |
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