Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis
CD4+ T follicular helper (Tfh) cells, a new subset of immune cells, have been demonstrated to be involved in granulomatous responses to Schistosoma japonicum (S. japonicum) infection. However, the role and underlying mechanisms of Tfh cell aggregation in S. japonicum infection remain incompletely un...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02154/full |
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| author | Quan Yang Jiale Qu Chenxi Jin Yuanfa Feng Shihao Xie Jinxin Zhu Gaoshen Liu Hongyan Xie Huaina Qiu Yanwei Qi Jianbing Mu Jun Huang Jun Huang |
| author_facet | Quan Yang Jiale Qu Chenxi Jin Yuanfa Feng Shihao Xie Jinxin Zhu Gaoshen Liu Hongyan Xie Huaina Qiu Yanwei Qi Jianbing Mu Jun Huang Jun Huang |
| author_sort | Quan Yang |
| collection | DOAJ |
| description | CD4+ T follicular helper (Tfh) cells, a new subset of immune cells, have been demonstrated to be involved in granulomatous responses to Schistosoma japonicum (S. japonicum) infection. However, the role and underlying mechanisms of Tfh cell aggregation in S. japonicum infection remain incompletely understood. In this study, we provide evidence that S. japonicum infection enhances the accumulation of Tfh cells in the spleen, lymph nodes, and peripheral blood of C57BL/6 mice. Infection-induced Tfh cells exhibited more potent effects directly on B cell responses than the control Tfh cells (P < 0.05). Furthermore, reduced apoptosis of Tfh cells was found both in S. japonicum infected mice and in soluble egg antigen (SEA) treated Tfh cells (P < 0.05). Mechanistic studies reveal that caspase-3 is the primary drivers of down-regulated apoptotic Tfh cell death in S. japonicum infection. In summary, this study demonstrates that Tfh cell accumulation might have an impact on the generation of immune responses in S. japonicum infection, and caspase-3 signaling mediated apoptosis down-regulation might responsible for the accumulation of Tfh cell in this course. |
| first_indexed | 2024-12-10T05:18:04Z |
| format | Article |
| id | doaj.art-a28a3217e5f14d6fbd57b90ab46823a8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T05:18:04Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a28a3217e5f14d6fbd57b90ab46823a82022-12-22T02:00:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-09-011010.3389/fimmu.2019.02154441350Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating ApoptosisQuan Yang0Jiale Qu1Chenxi Jin2Yuanfa Feng3Shihao Xie4Jinxin Zhu5Gaoshen Liu6Hongyan Xie7Huaina Qiu8Yanwei Qi9Jianbing Mu10Jun Huang11Jun Huang12Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United StatesGuangdong Provincial Key Laboratory of Allergy and Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, ChinaCD4+ T follicular helper (Tfh) cells, a new subset of immune cells, have been demonstrated to be involved in granulomatous responses to Schistosoma japonicum (S. japonicum) infection. However, the role and underlying mechanisms of Tfh cell aggregation in S. japonicum infection remain incompletely understood. In this study, we provide evidence that S. japonicum infection enhances the accumulation of Tfh cells in the spleen, lymph nodes, and peripheral blood of C57BL/6 mice. Infection-induced Tfh cells exhibited more potent effects directly on B cell responses than the control Tfh cells (P < 0.05). Furthermore, reduced apoptosis of Tfh cells was found both in S. japonicum infected mice and in soluble egg antigen (SEA) treated Tfh cells (P < 0.05). Mechanistic studies reveal that caspase-3 is the primary drivers of down-regulated apoptotic Tfh cell death in S. japonicum infection. In summary, this study demonstrates that Tfh cell accumulation might have an impact on the generation of immune responses in S. japonicum infection, and caspase-3 signaling mediated apoptosis down-regulation might responsible for the accumulation of Tfh cell in this course.https://www.frontiersin.org/article/10.3389/fimmu.2019.02154/fullSchistosoma japonicumT follicular helper (Tfh) cellsapoptosiscaspase-3SEA |
| spellingShingle | Quan Yang Jiale Qu Chenxi Jin Yuanfa Feng Shihao Xie Jinxin Zhu Gaoshen Liu Hongyan Xie Huaina Qiu Yanwei Qi Jianbing Mu Jun Huang Jun Huang Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis Frontiers in Immunology Schistosoma japonicum T follicular helper (Tfh) cells apoptosis caspase-3 SEA |
| title | Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis |
| title_full | Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis |
| title_fullStr | Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis |
| title_full_unstemmed | Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis |
| title_short | Schistosoma japonicum Infection Promotes the Response of Tfh Cells Through Down-Regulation of Caspase-3–Mediating Apoptosis |
| title_sort | schistosoma japonicum infection promotes the response of tfh cells through down regulation of caspase 3 mediating apoptosis |
| topic | Schistosoma japonicum T follicular helper (Tfh) cells apoptosis caspase-3 SEA |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02154/full |
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