Immune milieu and microbiome of the distal urethra in Ugandan men: impact of penile circumcision and implications for HIV susceptibility

Immune milieu and microbiome of the distal urethra in Ugandan men: impact of penile circumcision and implications for HIV susceptibility

Abstract Background Coronal sulcus (CS) anaerobe abundance and IL-8 levels are linked to HIV acquisition, and are dramatically reduced after penile circumcision (PC). The distal urethra may be the site of some HIV acquisition before PC, and presumably most acquisition post PC. We describe the immune...

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Bibliographic Details
Main Authors: Ronald M. Galiwango, Daniel E. Park, Sanja Huibner, Abigail Onos, Maliha Aziz, Kelsey Roach, Aggrey Anok, James Nnamutete, Yahaya Isabirye, John Bosco Wasswa, Deo Male, Godfrey Kigozi, Aaron A. R. Tobian, Jessica L. Prodger, Cindy M. Liu, Rupert Kaul
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Microbiome
Subjects:
Microbiome
Cytokines
Coronal sulcus
Penile urethra
Penile circumcision
Uganda
Online Access:https://doi.org/10.1186/s40168-021-01185-9

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