Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping
Abstract Background The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation without quantitative analysis in clinical practice. In this study, we aim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-021-00424-0 |
| _version_ | 1831674304661553152 |
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| author | Wonseok Whi Hongyoon Choi Jin Chul Paeng Gi Jeong Cheon Keon Wook Kang Dong Soo Lee |
| author_facet | Wonseok Whi Hongyoon Choi Jin Chul Paeng Gi Jeong Cheon Keon Wook Kang Dong Soo Lee |
| author_sort | Wonseok Whi |
| collection | DOAJ |
| description | Abstract Background The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation without quantitative analysis in clinical practice. In this study, we aimed to develop a fully automated quantitative interpretation pipeline of brain volume from an oncology PET image. Method We retrospectively collected 500 oncologic [18F]FDG-PET scans for training and validation of the automated brain extractor. We trained the model for extracting brain volume with two manually drawn bounding boxes on maximal intensity projection images. ResNet-50, a 2-D convolutional neural network (CNN), was used for the model training. The brain volume was automatically extracted using the CNN model and spatially normalized. For validation of the trained model and an application of this automated analytic method, we enrolled 24 subjects with small cell lung cancer (SCLC) and performed voxel-wise two-sample T test for automatic detection of metastatic lesions. Result The deep learning-based brain extractor successfully identified the existence of whole-brain volume, with an accuracy of 98% for the validation set. The performance of extracting the brain measured by the intersection-over-union of 3-D bounding boxes was 72.9 ± 12.5% for the validation set. As an example of the application to automatically identify brain abnormality, this approach successfully identified the metastatic lesions in three of the four cases of SCLC patients with brain metastasis. Conclusion Based on the deep learning-based model, extraction of the brain volume from whole-body PET was successfully performed. We suggest this fully automated approach could be used for the quantitative analysis of brain metabolic patterns to identify abnormalities during clinical interpretation of oncologic PET studies. |
| first_indexed | 2024-12-20T03:42:45Z |
| format | Article |
| id | doaj.art-a28bd4daf3b3432e8414859dba25bda2 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-12-20T03:42:45Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-a28bd4daf3b3432e8414859dba25bda22022-12-21T19:54:42ZengSpringerOpenEJNMMI Physics2197-73642021-11-018111010.1186/s40658-021-00424-0Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mappingWonseok Whi0Hongyoon Choi1Jin Chul Paeng2Gi Jeong Cheon3Keon Wook Kang4Dong Soo Lee5Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National UniversityDepartment of Nuclear Medicine, Seoul National University College of MedicineDepartment of Nuclear Medicine, Seoul National University College of MedicineDepartment of Nuclear Medicine, Seoul National University College of MedicineDepartment of Nuclear Medicine, Seoul National University College of MedicineDepartment of Nuclear Medicine, Seoul National University College of MedicineAbstract Background The whole brain is often covered in [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) in oncology patients, but the covered brain abnormality is typically screened by visual interpretation without quantitative analysis in clinical practice. In this study, we aimed to develop a fully automated quantitative interpretation pipeline of brain volume from an oncology PET image. Method We retrospectively collected 500 oncologic [18F]FDG-PET scans for training and validation of the automated brain extractor. We trained the model for extracting brain volume with two manually drawn bounding boxes on maximal intensity projection images. ResNet-50, a 2-D convolutional neural network (CNN), was used for the model training. The brain volume was automatically extracted using the CNN model and spatially normalized. For validation of the trained model and an application of this automated analytic method, we enrolled 24 subjects with small cell lung cancer (SCLC) and performed voxel-wise two-sample T test for automatic detection of metastatic lesions. Result The deep learning-based brain extractor successfully identified the existence of whole-brain volume, with an accuracy of 98% for the validation set. The performance of extracting the brain measured by the intersection-over-union of 3-D bounding boxes was 72.9 ± 12.5% for the validation set. As an example of the application to automatically identify brain abnormality, this approach successfully identified the metastatic lesions in three of the four cases of SCLC patients with brain metastasis. Conclusion Based on the deep learning-based model, extraction of the brain volume from whole-body PET was successfully performed. We suggest this fully automated approach could be used for the quantitative analysis of brain metabolic patterns to identify abnormalities during clinical interpretation of oncologic PET studies.https://doi.org/10.1186/s40658-021-00424-0Brain segmentationQuantitative PET analysisDeep learningConvolutional neural networkFDG-PETBrain FDG-PET |
| spellingShingle | Wonseok Whi Hongyoon Choi Jin Chul Paeng Gi Jeong Cheon Keon Wook Kang Dong Soo Lee Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping EJNMMI Physics Brain segmentation Quantitative PET analysis Deep learning Convolutional neural network FDG-PET Brain FDG-PET |
| title | Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping |
| title_full | Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping |
| title_fullStr | Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping |
| title_full_unstemmed | Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping |
| title_short | Fully automated identification of brain abnormality from whole-body FDG-PET imaging using deep learning-based brain extraction and statistical parametric mapping |
| title_sort | fully automated identification of brain abnormality from whole body fdg pet imaging using deep learning based brain extraction and statistical parametric mapping |
| topic | Brain segmentation Quantitative PET analysis Deep learning Convolutional neural network FDG-PET Brain FDG-PET |
| url | https://doi.org/10.1186/s40658-021-00424-0 |
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