Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/2/156 |
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| author | Yusuf S. Althobaiti |
| author_facet | Yusuf S. Althobaiti |
| author_sort | Yusuf S. Althobaiti |
| collection | DOAJ |
| description | Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based on the conditioned place preference (CPP) paradigm of drug addiction in a mouse model. First, mice received intraperitoneal injections of quetiapine (40, 80, or 120 mg/kg) every other day during the conditioning phase. In the second experiment, mice were pretreated with 0.03 mg/kg SKF-35866, a D1 receptor antagonist, before receiving saline or quetiapine (120 mg/kg) during the conditioning phase. No significant changes in time spent in the quetiapine-paired chamber were observed compared with time spent in the saline-paired chamber in mice treated with 40 or 80 mg/kg. In contrast, the preference to the quetiapine-paired chamber was significantly increased in mice treated with 120 mg/kg quetiapine, and this effect was blocked by SKF-35866 pretreatment. These results demonstrated, for the first time, the abuse potential of quetiapine in an animal model of drug addiction. Interestingly, this CPP-inducing effect was likely mediated by activating D1 receptors. |
| first_indexed | 2024-03-09T00:53:45Z |
| format | Article |
| id | doaj.art-a2902634c95348c4aab5b98057038a0e |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T00:53:45Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a2902634c95348c4aab5b98057038a0e2023-12-11T17:03:58ZengMDPI AGPharmaceuticals1424-82472021-02-0114215610.3390/ph14020156Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic PathwayYusuf S. Althobaiti0Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaQuetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based on the conditioned place preference (CPP) paradigm of drug addiction in a mouse model. First, mice received intraperitoneal injections of quetiapine (40, 80, or 120 mg/kg) every other day during the conditioning phase. In the second experiment, mice were pretreated with 0.03 mg/kg SKF-35866, a D1 receptor antagonist, before receiving saline or quetiapine (120 mg/kg) during the conditioning phase. No significant changes in time spent in the quetiapine-paired chamber were observed compared with time spent in the saline-paired chamber in mice treated with 40 or 80 mg/kg. In contrast, the preference to the quetiapine-paired chamber was significantly increased in mice treated with 120 mg/kg quetiapine, and this effect was blocked by SKF-35866 pretreatment. These results demonstrated, for the first time, the abuse potential of quetiapine in an animal model of drug addiction. Interestingly, this CPP-inducing effect was likely mediated by activating D1 receptors.https://www.mdpi.com/1424-8247/14/2/156quetiapinerewardconditioned place preferenceabuse |
| spellingShingle | Yusuf S. Althobaiti Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway Pharmaceuticals quetiapine reward conditioned place preference abuse |
| title | Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway |
| title_full | Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway |
| title_fullStr | Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway |
| title_full_unstemmed | Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway |
| title_short | Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway |
| title_sort | quetiapine induced place preference in mice possible dopaminergic pathway |
| topic | quetiapine reward conditioned place preference abuse |
| url | https://www.mdpi.com/1424-8247/14/2/156 |
| work_keys_str_mv | AT yusufsalthobaiti quetiapineinducedplacepreferenceinmicepossibledopaminergicpathway |