Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress

Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress

Background: Ulcerative colitis (UC) is one type of inflammatory bowel disease, characterized by inflammation with infiltration and activation of macrophages in colonic tissue. LH011 is a trypsin inhibitor with potential anti-inflammatory effect.Purpose: Here, we aim to assay the effects of LH011 on...

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Bibliographic Details
Main Authors: Zhenmao Jia, Panxia Wang, Yuansheng Xu, Guodong Feng, Quan Wang, Xiangjun He, Yan Song, Peiqing Liu, Jianwen Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
UC
LH011
inflammation
oxidative stress
NF-κB
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.986510/full

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