Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line

Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line

Objective. This study aimed to investigate the chemosensitive augmentation effect and mechanism of HDAC inhibitor Vorinostat (SAHA) in combination with arsenic trioxide (ATO) on proliferation and apoptosis of K562 cells.Methods. The CCK-8 assay was used to compare proliferation of the cells. Annexin...

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Bibliographic Details
Main Authors: Nainong Li, Xiaoyan Guan, Fang Li, Xiaofan Li, Yuanzhong Chen
Format: Article
Language:English
Published: PeerJ Inc. 2015-05-01
Series:PeerJ
Subjects:
Histone deacetylase inhibitors
Arsenic trioxide
K562 cell
Apoptosis
Online Access:https://peerj.com/articles/962.pdf

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