Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.

Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.

Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the gener...

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Bibliographic Details
Main Authors: Robert eHilbrands, Ye eChen, Adrian eKendal, Elizabeth eAdams, Stephen Paul Cobbold, Herman eWaldmann, Duncan eHowie
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
Antigens
Transplantation Immunology
Transplantation, Heterologous
T cells
Foxp3
regulatory T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00124/full
Description
Summary:Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3+Treg. Here we show that both in vitro and in vivo generated antigen specific Foxp3+Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.
ISSN:1664-3224

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