Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the gener...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00124/full |
| _version_ | 1819294463190630400 |
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| author | Robert eHilbrands Ye eChen Adrian eKendal Elizabeth eAdams Stephen Paul Cobbold Herman eWaldmann Duncan eHowie |
| author_facet | Robert eHilbrands Ye eChen Adrian eKendal Elizabeth eAdams Stephen Paul Cobbold Herman eWaldmann Duncan eHowie |
| author_sort | Robert eHilbrands |
| collection | DOAJ |
| description | Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3+Treg. Here we show that both in vitro and in vivo generated antigen specific Foxp3+Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model. |
| first_indexed | 2024-12-24T04:26:43Z |
| format | Article |
| id | doaj.art-a2922d94f4094c42be8646fcc58bd216 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T04:26:43Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a2922d94f4094c42be8646fcc58bd2162022-12-21T17:15:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-04-01710.3389/fimmu.2016.00124187702Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.Robert eHilbrands0Ye eChen1Adrian eKendal2Elizabeth eAdams3Stephen Paul Cobbold4Herman eWaldmann5Duncan eHowie6Oxford UniversityThe Royal Victorian Eye and Ear hospitalOxford UniversityOxford UniversityOxford UniversityOxford UniversityOxford UniversityRegulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3+Treg. Here we show that both in vitro and in vivo generated antigen specific Foxp3+Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00124/fullAntigensTransplantation ImmunologyTransplantation, HeterologousT cellsFoxp3regulatory T cells |
| spellingShingle | Robert eHilbrands Ye eChen Adrian eKendal Elizabeth eAdams Stephen Paul Cobbold Herman eWaldmann Duncan eHowie Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. Frontiers in Immunology Antigens Transplantation Immunology Transplantation, Heterologous T cells Foxp3 regulatory T cells |
| title | Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. |
| title_full | Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. |
| title_fullStr | Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. |
| title_full_unstemmed | Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. |
| title_short | Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells. |
| title_sort | induced foxp3 t cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory t cells |
| topic | Antigens Transplantation Immunology Transplantation, Heterologous T cells Foxp3 regulatory T cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00124/full |
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