Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation
Skin injuries, and especially wounds of chronic nature, can cause a major negative impact on the quality of life. New efficient alternatives are needed for wound healing therapy and herbal products are being investigated due to a high content of natural compounds with promising healing activity. For...
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MDPI AG
2022-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/3/1359 |
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| author | Daliana Minda Roxana Ghiulai Christian Dragos Banciu Ioana Zinuca Pavel Corina Danciu Roxana Racoviceanu Codruta Soica Oana Daniela Budu Delia Muntean Zorita Diaconeasa Cristina Adriana Dehelean Stefana Avram |
| author_facet | Daliana Minda Roxana Ghiulai Christian Dragos Banciu Ioana Zinuca Pavel Corina Danciu Roxana Racoviceanu Codruta Soica Oana Daniela Budu Delia Muntean Zorita Diaconeasa Cristina Adriana Dehelean Stefana Avram |
| author_sort | Daliana Minda |
| collection | DOAJ |
| description | Skin injuries, and especially wounds of chronic nature, can cause a major negative impact on the quality of life. New efficient alternatives are needed for wound healing therapy and herbal products are being investigated due to a high content of natural compounds with promising healing activity. For this purpose, we investigated three <i>Artemisia</i> species, <i>Artemisia absinthium</i> L. (AAb), <i>Artemisia dracunculus</i> L. (ADr) and <i>Artemisia annua</i> L. (AAn). Ethanolic extracts, containing different polyphenolic compounds, elicited strong antioxidant activities in the DPPH assay, comparable to ascorbic acid. Human ketratinocyte proliferation was stimulated and wound closure was enhanced by all three extracts at concentrations of 100 µg/mL. The <i>Artemisia</i> extracts modulated angiogenesis by increasing vessel formation, especially following treatment with <i>A. annua</i> and <i>A. dracunculus</i>, extracts with a significantly higher content of chlorogenic acid. Good tolerability and anti-irritative effects were also registered in ovo, on the chorioallantoic membrane (CAM). The three <i>Artemisia</i> species represent promising low-cost, polyphenol-rich, antioxidant, safe alternatives for wound care treatment. |
| first_indexed | 2024-03-10T00:13:15Z |
| format | Article |
| id | doaj.art-a29285bb65f145f3a4e46a16a71b7b0f |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:13:15Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-a29285bb65f145f3a4e46a16a71b7b0f2023-11-23T15:56:12ZengMDPI AGApplied Sciences2076-34172022-01-01123135910.3390/app12031359Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo EvaluationDaliana Minda0Roxana Ghiulai1Christian Dragos Banciu2Ioana Zinuca Pavel3Corina Danciu4Roxana Racoviceanu5Codruta Soica6Oana Daniela Budu7Delia Muntean8Zorita Diaconeasa9Cristina Adriana Dehelean10Stefana Avram11Department of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Internal Medicine IV, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Internal Medicine IV, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Microbiology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Food Science and Technology, Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine, Calea Manastur, 3-5, RO-400372 Cluj-Napoca, RomaniaResearch Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, RO-300041 Timişoara, RomaniaSkin injuries, and especially wounds of chronic nature, can cause a major negative impact on the quality of life. New efficient alternatives are needed for wound healing therapy and herbal products are being investigated due to a high content of natural compounds with promising healing activity. For this purpose, we investigated three <i>Artemisia</i> species, <i>Artemisia absinthium</i> L. (AAb), <i>Artemisia dracunculus</i> L. (ADr) and <i>Artemisia annua</i> L. (AAn). Ethanolic extracts, containing different polyphenolic compounds, elicited strong antioxidant activities in the DPPH assay, comparable to ascorbic acid. Human ketratinocyte proliferation was stimulated and wound closure was enhanced by all three extracts at concentrations of 100 µg/mL. The <i>Artemisia</i> extracts modulated angiogenesis by increasing vessel formation, especially following treatment with <i>A. annua</i> and <i>A. dracunculus</i>, extracts with a significantly higher content of chlorogenic acid. Good tolerability and anti-irritative effects were also registered in ovo, on the chorioallantoic membrane (CAM). The three <i>Artemisia</i> species represent promising low-cost, polyphenol-rich, antioxidant, safe alternatives for wound care treatment.https://www.mdpi.com/2076-3417/12/3/1359<i>Artemisia annua</i><i>Artemisia dracunculus</i><i>Artemisia absinthium</i>polyphenolswound healingkeratinocytes |
| spellingShingle | Daliana Minda Roxana Ghiulai Christian Dragos Banciu Ioana Zinuca Pavel Corina Danciu Roxana Racoviceanu Codruta Soica Oana Daniela Budu Delia Muntean Zorita Diaconeasa Cristina Adriana Dehelean Stefana Avram Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation Applied Sciences <i>Artemisia annua</i> <i>Artemisia dracunculus</i> <i>Artemisia absinthium</i> polyphenols wound healing keratinocytes |
| title | Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation |
| title_full | Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation |
| title_fullStr | Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation |
| title_full_unstemmed | Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation |
| title_short | Phytochemical Profile, Antioxidant and Wound Healing Potential of Three <i>Artemisia</i> Species: In Vitro and In Ovo Evaluation |
| title_sort | phytochemical profile antioxidant and wound healing potential of three i artemisia i species in vitro and in ovo evaluation |
| topic | <i>Artemisia annua</i> <i>Artemisia dracunculus</i> <i>Artemisia absinthium</i> polyphenols wound healing keratinocytes |
| url | https://www.mdpi.com/2076-3417/12/3/1359 |
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