Neurotrophic basis to the pathogenesis of depression and phytotherapy
Depression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to con...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1182666/full |
| _version_ | 1827972050886590464 |
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| author | Huiqin Wang Huiqin Wang Yantao Yang Gang Pei Zhenzhen Wang Naihong Chen Naihong Chen |
| author_facet | Huiqin Wang Huiqin Wang Yantao Yang Gang Pei Zhenzhen Wang Naihong Chen Naihong Chen |
| author_sort | Huiqin Wang |
| collection | DOAJ |
| description | Depression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to conventional antidepressants that may minimize undesirable adverse reactions. Thus, further research into the interaction between neurotrophic factors and depression and phytochemicals that repair neurotrophic factors deficit is highly required. This review highlighted the implication of neurotrophic factors in depression, with a focus on the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and detailed the antidepressant activities of various phytochemicals targeting neurotrophic factors. Additionally, we presented future opportunities for novel diagnostic and therapeutic strategies for depression and provided solutions to challenges in this area to accelerate the clinical translation of neurotrophic factors for the treatment of depression. |
| first_indexed | 2024-04-09T19:17:04Z |
| format | Article |
| id | doaj.art-a293fba4f7ed4661ac3422f4630a5908 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:17:04Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a293fba4f7ed4661ac3422f4630a59082023-04-06T04:27:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11826661182666Neurotrophic basis to the pathogenesis of depression and phytotherapyHuiqin Wang0Huiqin Wang1Yantao Yang2Gang Pei3Zhenzhen Wang4Naihong Chen5Naihong Chen6Hunan University of Chinese Medicine and Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, Hunan, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaHunan University of Chinese Medicine and Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, Hunan, ChinaHunan University of Chinese Medicine and Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, Hunan, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaHunan University of Chinese Medicine and Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, Hunan, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to conventional antidepressants that may minimize undesirable adverse reactions. Thus, further research into the interaction between neurotrophic factors and depression and phytochemicals that repair neurotrophic factors deficit is highly required. This review highlighted the implication of neurotrophic factors in depression, with a focus on the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and detailed the antidepressant activities of various phytochemicals targeting neurotrophic factors. Additionally, we presented future opportunities for novel diagnostic and therapeutic strategies for depression and provided solutions to challenges in this area to accelerate the clinical translation of neurotrophic factors for the treatment of depression.https://www.frontiersin.org/articles/10.3389/fphar.2023.1182666/fulldepressionneurotrophic factorspathogenesisneurotrophic basisphytotherapyphytochemicals |
| spellingShingle | Huiqin Wang Huiqin Wang Yantao Yang Gang Pei Zhenzhen Wang Naihong Chen Naihong Chen Neurotrophic basis to the pathogenesis of depression and phytotherapy Frontiers in Pharmacology depression neurotrophic factors pathogenesis neurotrophic basis phytotherapy phytochemicals |
| title | Neurotrophic basis to the pathogenesis of depression and phytotherapy |
| title_full | Neurotrophic basis to the pathogenesis of depression and phytotherapy |
| title_fullStr | Neurotrophic basis to the pathogenesis of depression and phytotherapy |
| title_full_unstemmed | Neurotrophic basis to the pathogenesis of depression and phytotherapy |
| title_short | Neurotrophic basis to the pathogenesis of depression and phytotherapy |
| title_sort | neurotrophic basis to the pathogenesis of depression and phytotherapy |
| topic | depression neurotrophic factors pathogenesis neurotrophic basis phytotherapy phytochemicals |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1182666/full |
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