Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement

Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement

To combat infectious diseases, vaccines are considered the best prophylactic strategy for a wide range of the population, but even when vaccines are effective, the administration of therapeutic antibodies against viruses could provide further treatment options, particularly for vulnerable groups who...

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Bibliographic Details
Main Authors: Zenjiro Sampei, Christine Xing’er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa, Siok Wan Gan, Takeru Nambu, Adrian Ho, Kiyofumi Honda, Tomoyuki Igawa, Fariyal Ahmed, Cheng-I Wang, Katja Fink, Junichi Nezu
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antibodies
Subjects:
antibody engineering
Fc engineering
anti-virus antibody
complement
C1q
Fcγ receptor
Online Access:https://www.mdpi.com/2073-4468/12/2/36

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