Chloroquine-Induced Accumulation of Autophagosomes and Lipids in the Endothelium

Chloroquine-Induced Accumulation of Autophagosomes and Lipids in the Endothelium

Chloroquine (CQ) is an antimalarial drug known to inhibit autophagy flux by impairing autophagosome–lysosome fusion. We hypothesized that autophagy flux altered by CQ has a considerable influence on the lipid composition of endothelial cells. Thus, we investigated endothelial responses induced by CQ...

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Bibliographic Details
Main Authors: Ewelina Bik, Lukasz Mateuszuk, Jagoda Orleanska, Malgorzata Baranska, Stefan Chlopicki, Katarzyna Majzner
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
endothelium
Chloroquine
lipids
lysosomotropism
Raman imaging
fluorescence imaging
Online Access:https://www.mdpi.com/1422-0067/22/5/2401

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