Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Partici...
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Associação Brasileira de Divulgação Científica
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| Series: | Brazilian Journal of Medical and Biological Research |
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| author | A.K. Fuzikawa S.V. Peixoto M. Taufer E.H. Moriguchi M.F. Lima-Costa |
| author_facet | A.K. Fuzikawa S.V. Peixoto M. Taufer E.H. Moriguchi M.F. Lima-Costa |
| author_sort | A.K. Fuzikawa |
| collection | DOAJ |
| description | Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ³140 mmHg and/or a diastolic blood pressure ³90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoE genotype as follows: e3 carriers, e3e3; e2 carriers, e2e2 or e2e3, and e4 carriers, e3e4 or e4e4. Potential confounding variables were age, gender, traditional cardiovascular risk factors, uric acid, and creatinine levels. The prevalence of hypertension was 61.3%. Compared with the e3 homozygotes, neither the e2 nor the e4 carrier status was associated with hypertension (adjusted prevalence ratios = 0.94, 95%CI = 0.83-1.07 and 0.98, 0.89-1.07, respectively). On the other hand, the e2 allele carriers had lower LDL cholesterol levels (P < 0.001) and the e4 carriers had higher LDL cholesterol levels (P = 0.036). This study provides epidemiologic evidence that the ApoE genotype is not associated with prevalent hypertension in old age. |
| first_indexed | 2024-04-13T06:25:47Z |
| format | Article |
| id | doaj.art-a29a4f22884f4cab9617c5239932687c |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-13T06:25:47Z |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-a29a4f22884f4cab9617c5239932687c2022-12-22T02:58:27ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X412899410.1590/S0100-879X2008000200002S0100-879X2008000200002Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)A.K. Fuzikawa0S.V. Peixoto1M. Taufer2E.H. Moriguchi3M.F. Lima-Costa4Universidade Federal de Minas GeraisUniversidade Federal de Minas GeraisCMIC Brasil Pesquisas ClínicasHospital Moinhos de VentoUniversidade Federal de Minas GeraisApolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ³140 mmHg and/or a diastolic blood pressure ³90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoE genotype as follows: e3 carriers, e3e3; e2 carriers, e2e2 or e2e3, and e4 carriers, e3e4 or e4e4. Potential confounding variables were age, gender, traditional cardiovascular risk factors, uric acid, and creatinine levels. The prevalence of hypertension was 61.3%. Compared with the e3 homozygotes, neither the e2 nor the e4 carrier status was associated with hypertension (adjusted prevalence ratios = 0.94, 95%CI = 0.83-1.07 and 0.98, 0.89-1.07, respectively). On the other hand, the e2 allele carriers had lower LDL cholesterol levels (P < 0.001) and the e4 carriers had higher LDL cholesterol levels (P = 0.036). This study provides epidemiologic evidence that the ApoE genotype is not associated with prevalent hypertension in old age.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200002&lng=en&tlng=enApolipoprotein EHypertensionLow-density lipoprotein cholesterolTriglyceridesLipid metabolism |
| spellingShingle | A.K. Fuzikawa S.V. Peixoto M. Taufer E.H. Moriguchi M.F. Lima-Costa Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) Brazilian Journal of Medical and Biological Research Apolipoprotein E Hypertension Low-density lipoprotein cholesterol Triglycerides Lipid metabolism |
| title | Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) |
| title_full | Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) |
| title_fullStr | Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) |
| title_full_unstemmed | Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) |
| title_short | Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) |
| title_sort | association of apoe polymorphisms with prevalent hypertension in 1406 older adults the bambui health aging study bhas |
| topic | Apolipoprotein E Hypertension Low-density lipoprotein cholesterol Triglycerides Lipid metabolism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200002&lng=en&tlng=en |
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