ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS
Introduction/Objective: Sickle cell anemia (SCA) is the most prevalent hemoglobinopathy in the world, with estimates indicating that 2% to 4% of the Brazilian population carries the Hemoglobin S gene. The objective of this study was to evaluate the association between hematological and clinical data...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923004443 |
| _version_ | 1827788654240595968 |
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| author | MOO Nascimento MMP Luciano EJS Freitas ACS Castro IPC Tavares JNV Silva SRL Albuquerque RS Leal MS Gonçalves JPM Neto |
| author_facet | MOO Nascimento MMP Luciano EJS Freitas ACS Castro IPC Tavares JNV Silva SRL Albuquerque RS Leal MS Gonçalves JPM Neto |
| author_sort | MOO Nascimento |
| collection | DOAJ |
| description | Introduction/Objective: Sickle cell anemia (SCA) is the most prevalent hemoglobinopathy in the world, with estimates indicating that 2% to 4% of the Brazilian population carries the Hemoglobin S gene. The objective of this study was to evaluate the association between hematological and clinical data in SCA patients treated at the Hematology and Hemotherapy Foundation of Amazonas (HEMOAM). Materials and methods: This work followed the cross-sectional study with a total of 261 SCA patients of the both genders. Hematological and clinical data were obtained through access to medical records. Statistical analysis was performed using the SPSS software, version 20, according to each variable, with significant differences being considered when p < 0.05. Results: The study population consisted mostly of patients from Manaus (56%), and the majority were female (56.9%), a predominance of brown race (77.39%), followed by white (14.94%) and black (7.66%). A significant difference was found to levels of reticulocytes between Caucasians (9.5 ± 6.7), compared to Brown (8.6 ± 6.2) and Black (5.1 ± 3.4) (p = 0.032). The levels of red blood cells in black patients were high (3.3 ± 0.87) compared to white (2.8 ± 0.58) and brown (2.90 ± 0.73) (p = 0,035). The lower leukocyte levels were found in black patients (10.3 ± 0.45), followed by white (11.1 ± 0.43) and brown race (12.3 ± 0.63). Discussion: The hematological profile of patients with SCA is extremely variable from one individual to another, with differences in the number and intensity of the hemolysis crisis episodes. Our results demonstrating the predominant brown race corroborate the number of SCA patients followed up in Brazilian Reference Centers. Conclusion: We believe that knowledge of the association between the hematological and sociodemographic profile of the population served by HEMOAM, especially patients from the interior of the state, can help to clarify the identification and diagnosis for these communities, in order to increase the presence of the state to mainly avoid underreporting and improve diagnosis. |
| first_indexed | 2024-03-11T17:08:36Z |
| format | Article |
| id | doaj.art-a29ab94a120a498abe9e89a6a47f75b0 |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-03-11T17:08:36Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-a29ab94a120a498abe9e89a6a47f75b02023-10-20T06:41:02ZengElsevierHematology, Transfusion and Cell Therapy2531-13792023-10-0145S107S108ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONASMOO Nascimento0MMP Luciano1EJS Freitas2ACS Castro3IPC Tavares4JNV Silva5SRL Albuquerque6RS Leal7MS Gonçalves8JPM Neto9Pós-Graduação em Ciências Farmacêuticas (PPGCF), Universidade Federal do Amazonas (UFAM), Manaus, BrazilPós-Graduação em Ciências Farmacêuticas (PPGCF), Universidade Federal do Amazonas (UFAM), Manaus, BrazilPós-Graduação em Imunologia Básica e Aplicada (PPGIBA), Universidade Federal do Amazonas (UFAM), Manaus, BrazilPós-graduação em Ciências Aplicadas à Hematologia (PPGH), Universidade do Estado do Amazonas (UEA), Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, BrasilPós-Graduação em Imunologia Básica e Aplicada (PPGIBA), Universidade Federal do Amazonas (UFAM), Manaus, BrazilPós-graduação em Ciências Aplicadas à Hematologia (PPGH), Universidade do Estado do Amazonas (UEA), Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, BrasilPós-graduação em Ciências Aplicadas à Hematologia (PPGH), Universidade do Estado do Amazonas (UEA), Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, BrasilPós-Graduação em Farmácia (PPGFAR), Universidade Federal da Bahia (UFBA), Salvador, BrazilInstituto Oswaldo Cruz Salvador (CPqGM), Salvador, BrazilPós-Graduação em Ciências Farmacêuticas (PPGCF), Universidade Federal do Amazonas (UFAM), Manaus, Brazil; Pós-Graduação em Imunologia Básica e Aplicada (PPGIBA), Universidade Federal do Amazonas (UFAM), Manaus, Brazil; Pós-graduação em Ciências Aplicadas à Hematologia (PPGH), Universidade do Estado do Amazonas (UEA), Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM, BrasilIntroduction/Objective: Sickle cell anemia (SCA) is the most prevalent hemoglobinopathy in the world, with estimates indicating that 2% to 4% of the Brazilian population carries the Hemoglobin S gene. The objective of this study was to evaluate the association between hematological and clinical data in SCA patients treated at the Hematology and Hemotherapy Foundation of Amazonas (HEMOAM). Materials and methods: This work followed the cross-sectional study with a total of 261 SCA patients of the both genders. Hematological and clinical data were obtained through access to medical records. Statistical analysis was performed using the SPSS software, version 20, according to each variable, with significant differences being considered when p < 0.05. Results: The study population consisted mostly of patients from Manaus (56%), and the majority were female (56.9%), a predominance of brown race (77.39%), followed by white (14.94%) and black (7.66%). A significant difference was found to levels of reticulocytes between Caucasians (9.5 ± 6.7), compared to Brown (8.6 ± 6.2) and Black (5.1 ± 3.4) (p = 0.032). The levels of red blood cells in black patients were high (3.3 ± 0.87) compared to white (2.8 ± 0.58) and brown (2.90 ± 0.73) (p = 0,035). The lower leukocyte levels were found in black patients (10.3 ± 0.45), followed by white (11.1 ± 0.43) and brown race (12.3 ± 0.63). Discussion: The hematological profile of patients with SCA is extremely variable from one individual to another, with differences in the number and intensity of the hemolysis crisis episodes. Our results demonstrating the predominant brown race corroborate the number of SCA patients followed up in Brazilian Reference Centers. Conclusion: We believe that knowledge of the association between the hematological and sociodemographic profile of the population served by HEMOAM, especially patients from the interior of the state, can help to clarify the identification and diagnosis for these communities, in order to increase the presence of the state to mainly avoid underreporting and improve diagnosis.http://www.sciencedirect.com/science/article/pii/S2531137923004443 |
| spellingShingle | MOO Nascimento MMP Luciano EJS Freitas ACS Castro IPC Tavares JNV Silva SRL Albuquerque RS Leal MS Gonçalves JPM Neto ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS Hematology, Transfusion and Cell Therapy |
| title | ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS |
| title_full | ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS |
| title_fullStr | ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS |
| title_full_unstemmed | ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS |
| title_short | ASSOCIATION BETWEEN HEMATOLOGICAL AND CLINICAL DATA OF THE SCA PATIENTS ASSISTED AT HEMATOLOGY AND HEMOTHERAPY CENTER IN AMAZONAS |
| title_sort | association between hematological and clinical data of the sca patients assisted at hematology and hemotherapy center in amazonas |
| url | http://www.sciencedirect.com/science/article/pii/S2531137923004443 |
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