Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population
Traditional lipid parameters—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)—have long been used as indicators of cardiovascular disease (CVD) risk. The labor...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/14/3/169 |
| _version_ | 1797240086090219520 |
|---|---|
| author | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_facet | Rihwa Choi Sang Gon Lee Eun Hee Lee |
| author_sort | Rihwa Choi |
| collection | DOAJ |
| description | Traditional lipid parameters—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)—have long been used as indicators of cardiovascular disease (CVD) risk. The laboratory records of 9604 Korean adults who underwent traditional lipid panel tests (TC, TG, and HDL), as well as ApoB testing, were analyzed to evaluate the prevalence of dyslipidemia and high CVD risk (utilizing the NCEP ATP III criteria for traditional lipid panels and various ApoB test cutoffs recommended by international guidelines (145 mg/dL, 130 mg/dL, and 100 mg/dL)). The overall prevalence of dyslipidemia, as determined by traditional lipid panel criteria, was 27.4%. Utilizing the ApoB cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL resulted in prevalence figures of 5.3%, 11.0%, and 36.3%, respectively. The concordance in dyslipidemia classification between traditional lipid tests and ApoB at cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL was 78.4%, 81.3%, and 74.7%, respectively. Up to 17.5% of participants, based on an ApoB cutoff of ≥100 mg/dL, exhibited isolated high ApoB in the absence of traditional lipid test anomalies. Incorporating ApoB testing could enhance the identification of Koreans at high CVD risk. |
| first_indexed | 2024-04-24T18:01:50Z |
| format | Article |
| id | doaj.art-a29b978cc35d4e1ea813c386fa46a3ad |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-04-24T18:01:50Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-a29b978cc35d4e1ea813c386fa46a3ad2024-03-27T13:54:11ZengMDPI AGMetabolites2218-19892024-03-0114316910.3390/metabo14030169Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult PopulationRihwa Choi0Sang Gon Lee1Eun Hee Lee2Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of KoreaDepartment of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of KoreaGreen Cross Laboratories, Yongin 16924, Republic of KoreaTraditional lipid parameters—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)—have long been used as indicators of cardiovascular disease (CVD) risk. The laboratory records of 9604 Korean adults who underwent traditional lipid panel tests (TC, TG, and HDL), as well as ApoB testing, were analyzed to evaluate the prevalence of dyslipidemia and high CVD risk (utilizing the NCEP ATP III criteria for traditional lipid panels and various ApoB test cutoffs recommended by international guidelines (145 mg/dL, 130 mg/dL, and 100 mg/dL)). The overall prevalence of dyslipidemia, as determined by traditional lipid panel criteria, was 27.4%. Utilizing the ApoB cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL resulted in prevalence figures of 5.3%, 11.0%, and 36.3%, respectively. The concordance in dyslipidemia classification between traditional lipid tests and ApoB at cutoffs of 145 mg/dL, 130 mg/dL, and 100 mg/dL was 78.4%, 81.3%, and 74.7%, respectively. Up to 17.5% of participants, based on an ApoB cutoff of ≥100 mg/dL, exhibited isolated high ApoB in the absence of traditional lipid test anomalies. Incorporating ApoB testing could enhance the identification of Koreans at high CVD risk.https://www.mdpi.com/2218-1989/14/3/169apolipoprotein BApoBcutoffdyslipidemialipidRepublic of Korea |
| spellingShingle | Rihwa Choi Sang Gon Lee Eun Hee Lee Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population Metabolites apolipoprotein B ApoB cutoff dyslipidemia lipid Republic of Korea |
| title | Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population |
| title_full | Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population |
| title_fullStr | Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population |
| title_full_unstemmed | Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population |
| title_short | Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population |
| title_sort | effect of adding apolipoprotein b testing on the prevalence of dyslipidemia and risk of cardiovascular disease in the korean adult population |
| topic | apolipoprotein B ApoB cutoff dyslipidemia lipid Republic of Korea |
| url | https://www.mdpi.com/2218-1989/14/3/169 |
| work_keys_str_mv | AT rihwachoi effectofaddingapolipoproteinbtestingontheprevalenceofdyslipidemiaandriskofcardiovasculardiseaseinthekoreanadultpopulation AT sanggonlee effectofaddingapolipoproteinbtestingontheprevalenceofdyslipidemiaandriskofcardiovasculardiseaseinthekoreanadultpopulation AT eunheelee effectofaddingapolipoproteinbtestingontheprevalenceofdyslipidemiaandriskofcardiovasculardiseaseinthekoreanadultpopulation |