Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a widely used diagnostic and therapeutic procedure. Effective sedation is crucial to enhance patient comfort and optimize endoscopist performance. Various sedation protocols, including Propofol and Dexmedetomidine (Pro-Dex), Ketami...
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Elsevier
2024-03-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024034789 |
| _version_ | 1827316409437257728 |
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| author | Ning Zhang Guanjun Li |
| author_facet | Ning Zhang Guanjun Li |
| author_sort | Ning Zhang |
| collection | DOAJ |
| description | Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a widely used diagnostic and therapeutic procedure. Effective sedation is crucial to enhance patient comfort and optimize endoscopist performance. Various sedation protocols, including Propofol and Dexmedetomidine (Pro-Dex), Ketamine and Propofol (Keto-Fol), Propofol and Midazolam (Pro-Mid), and Propofol alone, have been utilized during ERCP. This retrospective study aims to compare the safety and efficacy of these four sedation protocols. Methods: A retrospective analysis was conducted on data from 600 patients who underwent ERCP between 2018 and 2021, with each patient receiving one of the four sedation protocols. Protocol assignment was based on the endoscopist's preference. Data on hemodynamic parameters, sedation level, recovery time, and procedure-related complications were collected. Results: Baseline data showed no significant differences among the groups pre-procedure. The Pro-Dex group exhibited significantly lower mean total propofol dose, shorter recovery time, and faster achievement of Ramsay Sedation Scale (RSS) score 3–4 compared to the other groups. The Pro-group demonstrated significantly longer hospital stay than the other three groups (median, 4.19 ± 1.1 vs. 3.48 ± 1.2 days in the KP groups, p = 0.042). There were no significant variations in the incidence of respiratory depression, hypotension, or bradycardia among the four groups. Additionally, notable trends were found for hemodynamic measures, total propofol dosage, time to reach the desired level of sedation (as measured by the Ramsay Sedation Scale), and hospital stay based on BMI categories, indicating that higher BMI is linked to more serious outcomes. Conclusion: Our retrospective study demonstrates that the Pro-Dex protocol offers superior sedation quality, faster recovery, and fewer complications compared to the other protocols during ERCP. However, the incidence of ERCP-related adverse events did not significantly differ among the four sedation protocols. These findings can aid clinicians in selecting the most appropriate sedation protocol for ERCP, considering patient and endoscopist preferences. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-24T23:14:00Z |
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| series | Heliyon |
| spelling | doaj.art-a29e99de77a44efc87cbfad719462c672024-03-17T07:58:08ZengElsevierHeliyon2405-84402024-03-01105e27447Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective studyNing Zhang0Guanjun Li1Department of Cardiopulmonary Rehabilitation, Shandong Provincial Third Hospital, No.12, Wuyingshan Middle Road, Jinan, Shandong, 250000, ChinaDepartment of Anesthesiology, Shandong Provincial Third Hospital, No.12, Wuyingshan Middle Road, Jinan, Shandong, 250000, China; Corresponding author.Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a widely used diagnostic and therapeutic procedure. Effective sedation is crucial to enhance patient comfort and optimize endoscopist performance. Various sedation protocols, including Propofol and Dexmedetomidine (Pro-Dex), Ketamine and Propofol (Keto-Fol), Propofol and Midazolam (Pro-Mid), and Propofol alone, have been utilized during ERCP. This retrospective study aims to compare the safety and efficacy of these four sedation protocols. Methods: A retrospective analysis was conducted on data from 600 patients who underwent ERCP between 2018 and 2021, with each patient receiving one of the four sedation protocols. Protocol assignment was based on the endoscopist's preference. Data on hemodynamic parameters, sedation level, recovery time, and procedure-related complications were collected. Results: Baseline data showed no significant differences among the groups pre-procedure. The Pro-Dex group exhibited significantly lower mean total propofol dose, shorter recovery time, and faster achievement of Ramsay Sedation Scale (RSS) score 3–4 compared to the other groups. The Pro-group demonstrated significantly longer hospital stay than the other three groups (median, 4.19 ± 1.1 vs. 3.48 ± 1.2 days in the KP groups, p = 0.042). There were no significant variations in the incidence of respiratory depression, hypotension, or bradycardia among the four groups. Additionally, notable trends were found for hemodynamic measures, total propofol dosage, time to reach the desired level of sedation (as measured by the Ramsay Sedation Scale), and hospital stay based on BMI categories, indicating that higher BMI is linked to more serious outcomes. Conclusion: Our retrospective study demonstrates that the Pro-Dex protocol offers superior sedation quality, faster recovery, and fewer complications compared to the other protocols during ERCP. However, the incidence of ERCP-related adverse events did not significantly differ among the four sedation protocols. These findings can aid clinicians in selecting the most appropriate sedation protocol for ERCP, considering patient and endoscopist preferences.http://www.sciencedirect.com/science/article/pii/S2405844024034789Adverse eventsDexmedetomidineEndoscopic retrograde cholangiopancreatography (ERCP)KetaminePropofolSedation |
| spellingShingle | Ning Zhang Guanjun Li Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study Heliyon Adverse events Dexmedetomidine Endoscopic retrograde cholangiopancreatography (ERCP) Ketamine Propofol Sedation |
| title | Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study |
| title_full | Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study |
| title_fullStr | Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study |
| title_full_unstemmed | Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study |
| title_short | Comparing sedation protocols for endoscopic retrograde cholangiopancreatography (ERCP): A retrospective study |
| title_sort | comparing sedation protocols for endoscopic retrograde cholangiopancreatography ercp a retrospective study |
| topic | Adverse events Dexmedetomidine Endoscopic retrograde cholangiopancreatography (ERCP) Ketamine Propofol Sedation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024034789 |
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