Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

Background: DNA is the main target for UV-B-irradiation-induced skin photodamage and accounts for 90 % of all the non-melanoma skin cancers. Purpose: In this study, we explored the mechanistic basis of photoprotective effect of Trigonelline, a naturally occurring alkaloid from the Trigonella foenum-...

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Bibliographic Details
Main Authors: Malik A. Tanveer, Haroon Rashid, Lone A. Nazir, Sajida Archoo, Naiku H. Shahid, Gupta Ragni, Sheikh A. Umar, Sheikh A. Tasduq
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Experimental Gerontology
Subjects:
UV-B
Trigonelline
DNA damage
Oxidative stress
Antioxidants
Cosmeceutical agent
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556522003370

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