Effects of Testosterone Level on Lower Urinary Tract Symptoms
Lower urinary tract symptoms (LUTS) are common in older men and are frequently associated with benign prostatic hyperplasia (BPH). The relationship between BPH and endogenous total testosterone (TT) levels has been widely studied. The aim of this post hoc analysis was to determine the association be...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2016-09-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/1557988315590655 |
| _version_ | 1811333900320899072 |
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| author | E. David Crawford MD Wendy Poage MHA Allen Nyhuis MS David A. Price PhD Sherie A. Dowsett PhD David Muram MD |
| author_facet | E. David Crawford MD Wendy Poage MHA Allen Nyhuis MS David A. Price PhD Sherie A. Dowsett PhD David Muram MD |
| author_sort | E. David Crawford MD |
| collection | DOAJ |
| description | Lower urinary tract symptoms (LUTS) are common in older men and are frequently associated with benign prostatic hyperplasia (BPH). The relationship between BPH and endogenous total testosterone (TT) levels has been widely studied. The aim of this post hoc analysis was to determine the association between LUTS and endogenous TT levels in a subset of men participating in the 2013 Prostate Cancer Awareness Week, a U.S. community-based prostate cancer screening program. Men completed the International Prostate Symptom Score (I-PSS) questionnaire, prostate size was estimated by a digital rectal examination, and serum TT and prostate-specific antigen levels were measured. Mean TT levels (ng/dl) did not significantly correlate with prostate size category ( r = +.03, p = .69): normal, 419.2 ( n = 106); enlarged, 394.7 ( n = 71); abnormal, 416.4 ( n = 7); and abnormal/suspicious, 515.2 ( n = 19). Mean TT levels (ng/dl) did not significantly correlate with I-PSS category ( r = −.06, p = .40): none, 468.5 ( n = 15); mild, 414.0 ( n = 138); moderate, 397.4 ( n = 66); and severe, 437.9 ( n = 7). Mean TT levels (ng/dl) did not significantly correlate with I-PSS quality of life rating ( r = −.13, p = .055): delighted, 474.5 ( n = 43); pleased, 424.6 ( n = 65); mostly satisfied, 361.2 ( n = 63); mixed, 448.2 ( n = 29); mostly dissatisfied, 337.2 ( n = 17); and unhappy, 435.8 ( n = 6). Adjustment for prostate size or prostate-specific antigen levels yielded similar findings. In conclusion, endogenous TT levels did not correlate with LUTS or prostate size, and these findings support the saturation theory in which TT is not able to induce further androgen-stimulated prostate tissue growth due to receptor saturation. Any worsening of LUTS following testosterone replacement therapy in hypogonadal men may be related to stimulation of prostatic cells previously deprived of testosterone. |
| first_indexed | 2024-04-13T16:59:46Z |
| format | Article |
| id | doaj.art-a29f27a71ec3450d9a54b8aa2315ade9 |
| institution | Directory Open Access Journal |
| issn | 1557-9883 1557-9891 |
| language | English |
| last_indexed | 2024-04-13T16:59:46Z |
| publishDate | 2016-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-a29f27a71ec3450d9a54b8aa2315ade92022-12-22T02:38:42ZengSAGE PublishingAmerican Journal of Men's Health1557-98831557-98912016-09-011010.1177/1557988315590655Effects of Testosterone Level on Lower Urinary Tract SymptomsE. David Crawford MD0Wendy Poage MHA1Allen Nyhuis MS2David A. Price PhD3Sherie A. Dowsett PhD4David Muram MD5University of Colorado Hospital, Aurora, CO, USAProstate Conditions Education Council, Centennial, CO, USAEli Lilly and Company, Indianapolis, IN, USAEli Lilly and Company, Indianapolis, IN, USAEli Lilly and Company, Indianapolis, IN, USAEli Lilly and Company, Indianapolis, IN, USALower urinary tract symptoms (LUTS) are common in older men and are frequently associated with benign prostatic hyperplasia (BPH). The relationship between BPH and endogenous total testosterone (TT) levels has been widely studied. The aim of this post hoc analysis was to determine the association between LUTS and endogenous TT levels in a subset of men participating in the 2013 Prostate Cancer Awareness Week, a U.S. community-based prostate cancer screening program. Men completed the International Prostate Symptom Score (I-PSS) questionnaire, prostate size was estimated by a digital rectal examination, and serum TT and prostate-specific antigen levels were measured. Mean TT levels (ng/dl) did not significantly correlate with prostate size category ( r = +.03, p = .69): normal, 419.2 ( n = 106); enlarged, 394.7 ( n = 71); abnormal, 416.4 ( n = 7); and abnormal/suspicious, 515.2 ( n = 19). Mean TT levels (ng/dl) did not significantly correlate with I-PSS category ( r = −.06, p = .40): none, 468.5 ( n = 15); mild, 414.0 ( n = 138); moderate, 397.4 ( n = 66); and severe, 437.9 ( n = 7). Mean TT levels (ng/dl) did not significantly correlate with I-PSS quality of life rating ( r = −.13, p = .055): delighted, 474.5 ( n = 43); pleased, 424.6 ( n = 65); mostly satisfied, 361.2 ( n = 63); mixed, 448.2 ( n = 29); mostly dissatisfied, 337.2 ( n = 17); and unhappy, 435.8 ( n = 6). Adjustment for prostate size or prostate-specific antigen levels yielded similar findings. In conclusion, endogenous TT levels did not correlate with LUTS or prostate size, and these findings support the saturation theory in which TT is not able to induce further androgen-stimulated prostate tissue growth due to receptor saturation. Any worsening of LUTS following testosterone replacement therapy in hypogonadal men may be related to stimulation of prostatic cells previously deprived of testosterone.https://doi.org/10.1177/1557988315590655 |
| spellingShingle | E. David Crawford MD Wendy Poage MHA Allen Nyhuis MS David A. Price PhD Sherie A. Dowsett PhD David Muram MD Effects of Testosterone Level on Lower Urinary Tract Symptoms American Journal of Men's Health |
| title | Effects of Testosterone Level on Lower Urinary Tract Symptoms |
| title_full | Effects of Testosterone Level on Lower Urinary Tract Symptoms |
| title_fullStr | Effects of Testosterone Level on Lower Urinary Tract Symptoms |
| title_full_unstemmed | Effects of Testosterone Level on Lower Urinary Tract Symptoms |
| title_short | Effects of Testosterone Level on Lower Urinary Tract Symptoms |
| title_sort | effects of testosterone level on lower urinary tract symptoms |
| url | https://doi.org/10.1177/1557988315590655 |
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