The Role of Two Heart Biomarkers in IgA Nephropathy
Cardiovascular mortality is a leading cause of death in chronic kidney disease (CKD), as is IgA nephropathy (IgAN). The purpose of this study is to find different biomarkers to estimate the outcome of the disease, which is significantly influenced by the changes in vessels (characterized by arterial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10336 |
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| author | Balázs Sági Tibor Vas Rita Jakabfi-Csepregi Zoltán Horváth-Szalai Tamás Kőszegi Botond Csiky Judit Nagy Tibor József Kovács |
| author_facet | Balázs Sági Tibor Vas Rita Jakabfi-Csepregi Zoltán Horváth-Szalai Tamás Kőszegi Botond Csiky Judit Nagy Tibor József Kovács |
| author_sort | Balázs Sági |
| collection | DOAJ |
| description | Cardiovascular mortality is a leading cause of death in chronic kidney disease (CKD), as is IgA nephropathy (IgAN). The purpose of this study is to find different biomarkers to estimate the outcome of the disease, which is significantly influenced by the changes in vessels (characterized by arterial stiffness) and the heart. In our cross-sectional study, 90 patients with IgAN were examined. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) was measured as a heart failure biomarker by an automated immonoassay method, while the carboxy-terminal telopeptide of collagen type I (CITP) as a fibrosis marker was determined using ELISA kits. Arterial stiffness was determined by measuring carotid–femoral pulse wave velocity (cfPWV). Renal function and routine echocardiography examinations were performed as well. Based on eGFR, patients were separated into two categories, CKD 1-2 and CKD 3-5. There were significantly higher NT-proBNP (<i>p</i> = 0.035), cfPWV (<i>p</i> = 0.004), and central aortic systolic pressure (<i>p</i> = 0.037), but not CITP, in the CKD 3-5 group. Both biomarker positivities were significantly higher in the CKD 3-5 group (<i>p</i> = 0.035) compared to the CKD 1-2 group. The central aortic systolic pressure was significantly higher in the diastolic dysfunction group (<i>p</i> = 0.034), while the systolic blood pressure was not. eGFR and hemoglobin levels showed a strong negative correlation, while left ventricular mass index (LVMI), aortic pulse pressure, central aortic systolic pressure, and cfPWV showed a positive correlation with NT-proBNP. cfPWV, aortic pulse pressure, and LVMI showed a strong positive correlation with CITP. Only eGFR was an independent predictor of NT-proBNP by linear regression analysis. NT-proBNP and CITP biomarkers may help to identify IgAN patients at high risk for subclinical heart failure and further atherosclerotic disease. |
| first_indexed | 2024-03-11T02:20:35Z |
| format | Article |
| id | doaj.art-a29f5d0fdd064e7083250f6f4497d36f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:20:35Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a29f5d0fdd064e7083250f6f4497d36f2023-11-18T10:52:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121033610.3390/ijms241210336The Role of Two Heart Biomarkers in IgA NephropathyBalázs Sági0Tibor Vas1Rita Jakabfi-Csepregi2Zoltán Horváth-Szalai3Tamás Kőszegi4Botond Csiky5Judit Nagy6Tibor József Kovács72nd. Department of Internal Medicine and Nephrology, Diabetes Center, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary2nd. Department of Internal Medicine and Nephrology, Diabetes Center, Clinical Center, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary2nd. Department of Internal Medicine and Nephrology, Diabetes Center, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary2nd. Department of Internal Medicine and Nephrology, Diabetes Center, Clinical Center, Medical School, University of Pécs, 7624 Pécs, Hungary2nd. Department of Internal Medicine and Nephrology, Diabetes Center, Clinical Center, Medical School, University of Pécs, 7624 Pécs, HungaryCardiovascular mortality is a leading cause of death in chronic kidney disease (CKD), as is IgA nephropathy (IgAN). The purpose of this study is to find different biomarkers to estimate the outcome of the disease, which is significantly influenced by the changes in vessels (characterized by arterial stiffness) and the heart. In our cross-sectional study, 90 patients with IgAN were examined. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) was measured as a heart failure biomarker by an automated immonoassay method, while the carboxy-terminal telopeptide of collagen type I (CITP) as a fibrosis marker was determined using ELISA kits. Arterial stiffness was determined by measuring carotid–femoral pulse wave velocity (cfPWV). Renal function and routine echocardiography examinations were performed as well. Based on eGFR, patients were separated into two categories, CKD 1-2 and CKD 3-5. There were significantly higher NT-proBNP (<i>p</i> = 0.035), cfPWV (<i>p</i> = 0.004), and central aortic systolic pressure (<i>p</i> = 0.037), but not CITP, in the CKD 3-5 group. Both biomarker positivities were significantly higher in the CKD 3-5 group (<i>p</i> = 0.035) compared to the CKD 1-2 group. The central aortic systolic pressure was significantly higher in the diastolic dysfunction group (<i>p</i> = 0.034), while the systolic blood pressure was not. eGFR and hemoglobin levels showed a strong negative correlation, while left ventricular mass index (LVMI), aortic pulse pressure, central aortic systolic pressure, and cfPWV showed a positive correlation with NT-proBNP. cfPWV, aortic pulse pressure, and LVMI showed a strong positive correlation with CITP. Only eGFR was an independent predictor of NT-proBNP by linear regression analysis. NT-proBNP and CITP biomarkers may help to identify IgAN patients at high risk for subclinical heart failure and further atherosclerotic disease.https://www.mdpi.com/1422-0067/24/12/10336chronic kidney diseaseIgA nephropathyrenal functionheart failurearterial stiffness |
| spellingShingle | Balázs Sági Tibor Vas Rita Jakabfi-Csepregi Zoltán Horváth-Szalai Tamás Kőszegi Botond Csiky Judit Nagy Tibor József Kovács The Role of Two Heart Biomarkers in IgA Nephropathy International Journal of Molecular Sciences chronic kidney disease IgA nephropathy renal function heart failure arterial stiffness |
| title | The Role of Two Heart Biomarkers in IgA Nephropathy |
| title_full | The Role of Two Heart Biomarkers in IgA Nephropathy |
| title_fullStr | The Role of Two Heart Biomarkers in IgA Nephropathy |
| title_full_unstemmed | The Role of Two Heart Biomarkers in IgA Nephropathy |
| title_short | The Role of Two Heart Biomarkers in IgA Nephropathy |
| title_sort | role of two heart biomarkers in iga nephropathy |
| topic | chronic kidney disease IgA nephropathy renal function heart failure arterial stiffness |
| url | https://www.mdpi.com/1422-0067/24/12/10336 |
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