Stimulation of chitin synthesis rescues Candida albicans from echinocandins.

Stimulation of chitin synthesis rescues Candida albicans from echinocandins.

Echinocandins are a new generation of novel antifungal agent that inhibit cell wall beta(1,3)-glucan synthesis and are normally cidal for the human pathogen Candida albicans. Treatment of C. albicans with low levels of echinocandins stimulated chitin synthase (CHS) gene expression, increased Chs act...

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Bibliographic Details
Main Authors:	Louise A Walker, Carol A Munro, Irene de Bruijn, Megan D Lenardon, Alastair McKinnon, Neil A R Gow
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-04-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC2271054?pdf=render

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