Dysfunction of the meibomian glands in patients with diabetes mellitus
The prevalence of diabetes mellitus has increased in recent decades. The most common ophthalmic manifestations of diabetes mellitus are retinopathy, epitheliopathies, corneal erosion and dry eye syndrome, the symptoms of which are more pronounced than in people without diabetes. The meibomian glands...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2022-05-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12798 |
| _version_ | 1826587998565695488 |
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| author | T. N. Safonova E. S. Medvedeva |
| author_facet | T. N. Safonova E. S. Medvedeva |
| author_sort | T. N. Safonova |
| collection | DOAJ |
| description | The prevalence of diabetes mellitus has increased in recent decades. The most common ophthalmic manifestations of diabetes mellitus are retinopathy, epitheliopathies, corneal erosion and dry eye syndrome, the symptoms of which are more pronounced than in people without diabetes. The meibomian glands, which are the producer of various lipids, participate in the formation of the lipid layer of the tear film, which prevents the evaporation of the water-mucin phase and ensures the preservation of homeostasis of the ocular surface. Meibum is a lipid-rich secret produced by fully differentiated meibocytes. Impaired insulin secretion, insulin resistance, absolute insulin deficiency, as well as hyperglycemia, potentiate the development of oxidative stress and a cascade of metabolic changes, leading to a change in the anatomical and functional state of the meibomian glands, which affects the qualitative and quantitative secretion. Cytological abnormalities, as well as the structure of the excretory ducts of the meibomian glands in patients with long-term diabetes mellitus, were established using the method of laser scanning microscopy. Using the method of mass spectrometry, it is possible to determine the patterns of changes in the chemical composition of meibum in patients with diabetes mellitus. The data obtained can become one of the criteria for predicting the course, reflect the degree of compensation and / or progression of diabetes mellitus. |
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| format | Article |
| id | doaj.art-a2a0f3a6017d4e0bbed8b5c7cc270cfc |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:34:20Z |
| publishDate | 2022-05-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-a2a0f3a6017d4e0bbed8b5c7cc270cfc2025-02-21T09:29:38ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782022-05-0125218619110.14341/DM1279810937Dysfunction of the meibomian glands in patients with diabetes mellitusT. N. Safonova0E. S. Medvedeva1Research Institute of Eye DiseasesResearch Institute of Eye DiseasesThe prevalence of diabetes mellitus has increased in recent decades. The most common ophthalmic manifestations of diabetes mellitus are retinopathy, epitheliopathies, corneal erosion and dry eye syndrome, the symptoms of which are more pronounced than in people without diabetes. The meibomian glands, which are the producer of various lipids, participate in the formation of the lipid layer of the tear film, which prevents the evaporation of the water-mucin phase and ensures the preservation of homeostasis of the ocular surface. Meibum is a lipid-rich secret produced by fully differentiated meibocytes. Impaired insulin secretion, insulin resistance, absolute insulin deficiency, as well as hyperglycemia, potentiate the development of oxidative stress and a cascade of metabolic changes, leading to a change in the anatomical and functional state of the meibomian glands, which affects the qualitative and quantitative secretion. Cytological abnormalities, as well as the structure of the excretory ducts of the meibomian glands in patients with long-term diabetes mellitus, were established using the method of laser scanning microscopy. Using the method of mass spectrometry, it is possible to determine the patterns of changes in the chemical composition of meibum in patients with diabetes mellitus. The data obtained can become one of the criteria for predicting the course, reflect the degree of compensation and / or progression of diabetes mellitus.https://www.dia-endojournals.ru/jour/article/view/12798meibomian gland dysfunctionmeibumdiabetes mellituslipidomemass spectrometrydry eye syndrometear film |
| spellingShingle | T. N. Safonova E. S. Medvedeva Dysfunction of the meibomian glands in patients with diabetes mellitus Сахарный диабет meibomian gland dysfunction meibum diabetes mellitus lipidome mass spectrometry dry eye syndrome tear film |
| title | Dysfunction of the meibomian glands in patients with diabetes mellitus |
| title_full | Dysfunction of the meibomian glands in patients with diabetes mellitus |
| title_fullStr | Dysfunction of the meibomian glands in patients with diabetes mellitus |
| title_full_unstemmed | Dysfunction of the meibomian glands in patients with diabetes mellitus |
| title_short | Dysfunction of the meibomian glands in patients with diabetes mellitus |
| title_sort | dysfunction of the meibomian glands in patients with diabetes mellitus |
| topic | meibomian gland dysfunction meibum diabetes mellitus lipidome mass spectrometry dry eye syndrome tear film |
| url | https://www.dia-endojournals.ru/jour/article/view/12798 |
| work_keys_str_mv | AT tnsafonova dysfunctionofthemeibomianglandsinpatientswithdiabetesmellitus AT esmedvedeva dysfunctionofthemeibomianglandsinpatientswithdiabetesmellitus |