Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure
Metallothionein (MTs) is a family of low molecular weight peptides with high cysteine content. In aquatic invertebrates, MTs play an important role in the detoxification of metals and they are often cited as useful biomarkers for toxic metal stress. The change in concentrations of metallothionein in...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2012-03-01
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| Series: | Journal of Basic and Applied Zoology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090989612000264 |
| _version_ | 1819048939733647360 |
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| author | Mahmoud M.A. Desouky |
| author_facet | Mahmoud M.A. Desouky |
| author_sort | Mahmoud M.A. Desouky |
| collection | DOAJ |
| description | Metallothionein (MTs) is a family of low molecular weight peptides with high cysteine content. In aquatic invertebrates, MTs play an important role in the detoxification of metals and they are often cited as useful biomarkers for toxic metal stress. The change in concentrations of metallothionein in response to aluminum and cadmium exposure was investigated in the soft tissues of two freshwater molluscs: Lymnaea stagnalis and Dreissena polymorpha that have contrasting feeding behavior and therefore metal accumulation profiles. The majority of added Al had precipitated in the bottom of tanks within 24 h, with an average of only 15.4% and 26.2% remaining in the water column of tanks containing snails and mussels, respectively. In contrast, most of the Cd did not precipitate but remained in solution (81.1% and 82.7%, respectively) between water changes. Both metals accumulated in the soft tissues of both animals, but only cadmium exposure led to an increase in metallothionein concentrations in the soft tissues. However, no significant difference was observed in the level of total protein in both tested molluscs upon exposure to Al and Cd compared to the corresponding control. Therefore, care should be taken in the use of metallothioneins as biomarkers for metal stress, since not all metallic stressors induce their expression. |
| first_indexed | 2024-12-21T11:24:14Z |
| format | Article |
| id | doaj.art-a2a10f39837d41c19a48ff28cb202fc1 |
| institution | Directory Open Access Journal |
| issn | 2090-9896 |
| language | English |
| last_indexed | 2024-12-21T11:24:14Z |
| publishDate | 2012-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Basic and Applied Zoology |
| spelling | doaj.art-a2a10f39837d41c19a48ff28cb202fc12022-12-21T19:05:42ZengSpringerOpenJournal of Basic and Applied Zoology2090-98962012-03-0165213914310.1016/j.jobaz.2012.07.008Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposureMahmoud M.A. DesoukyMetallothionein (MTs) is a family of low molecular weight peptides with high cysteine content. In aquatic invertebrates, MTs play an important role in the detoxification of metals and they are often cited as useful biomarkers for toxic metal stress. The change in concentrations of metallothionein in response to aluminum and cadmium exposure was investigated in the soft tissues of two freshwater molluscs: Lymnaea stagnalis and Dreissena polymorpha that have contrasting feeding behavior and therefore metal accumulation profiles. The majority of added Al had precipitated in the bottom of tanks within 24 h, with an average of only 15.4% and 26.2% remaining in the water column of tanks containing snails and mussels, respectively. In contrast, most of the Cd did not precipitate but remained in solution (81.1% and 82.7%, respectively) between water changes. Both metals accumulated in the soft tissues of both animals, but only cadmium exposure led to an increase in metallothionein concentrations in the soft tissues. However, no significant difference was observed in the level of total protein in both tested molluscs upon exposure to Al and Cd compared to the corresponding control. Therefore, care should be taken in the use of metallothioneins as biomarkers for metal stress, since not all metallic stressors induce their expression.http://www.sciencedirect.com/science/article/pii/S2090989612000264Lymnaea stagnalisDreissena polymorphaAluminumCadmiumMetallothionein |
| spellingShingle | Mahmoud M.A. Desouky Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure Journal of Basic and Applied Zoology Lymnaea stagnalis Dreissena polymorpha Aluminum Cadmium Metallothionein |
| title | Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure |
| title_full | Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure |
| title_fullStr | Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure |
| title_full_unstemmed | Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure |
| title_short | Metallothionein is up-regulated in molluscan responses to cadmium, but not aluminum, exposure |
| title_sort | metallothionein is up regulated in molluscan responses to cadmium but not aluminum exposure |
| topic | Lymnaea stagnalis Dreissena polymorpha Aluminum Cadmium Metallothionein |
| url | http://www.sciencedirect.com/science/article/pii/S2090989612000264 |
| work_keys_str_mv | AT mahmoudmadesouky metallothioneinisupregulatedinmolluscanresponsestocadmiumbutnotaluminumexposure |