The Correlation between Alpha-fetoprotein and Liver Function Tests
Background Serum alpha-fetoprotein (AFP) level is a good indicator of important pathological stages in patients with chronic liver diseases. This study aims to investigate the alpha-fetoprotein level in male and female patients and to correlate it with other liver functions tests (LFTs), such as...
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| Format: | Article |
| Language: | English |
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University of Management and Technology
2019-12-01
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| Series: | Bioscientific Review |
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| Online Access: | https://journals.umt.edu.pk/index.php/BSR/article/view/516 |
| _version_ | 1811240531523534848 |
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| author | Shahid Ali Aqib Nazeer Imran Tipu |
| author_facet | Shahid Ali Aqib Nazeer Imran Tipu |
| author_sort | Shahid Ali |
| collection | DOAJ |
| description |
Background
Serum alpha-fetoprotein (AFP) level is a good indicator of important pathological stages in patients with chronic liver diseases. This study aims to investigate the alpha-fetoprotein level in male and female patients and to correlate it with other liver functions tests (LFTs), such as ALT, AST, total albumin and total protein.
Methods
A total of 100 patients within the age range 20-85 years who visited Shaukat Khanum Laboratory in Lahore were recruited for this study. Automated chemiluminicence microparticle immuno assay and immulite 2000 (CMIA, siemens USA) were used to measure serum AFP level. To measure serum ALT and AST, Architect 8200 kit (Abbott, USA) was used with a reference range of 0-50 U/L, according to the manufacturer’s protocols.
Results
Out of the total 100 samples (55 males, 45 females), 47 samples (47%) had normal AFP level (<5IU/l) and 53 samples (53%) had high AFP level (>5IU/l). A higher frequency of elevated AFP was observed in men at 60.38%. There was no significant correlation of AFP level with ALT (p= 0.38, r2= 0.002), T.P. (P. value= 0.7635 r2= 0.002) and albumin levels (p= 0.07, r2 =0.041). However, a significant correlation was found between AFP and AST levels (p= 0.02, r2= 0.15).
Conclusion
Our study found a higher AFP level in older population (>60) as compared to the younger people (20-40) and a higher frequency among males (60.38%) as compared to females (39.63%). It also found that AFP level significantly correlates with AST level but does not show any association with ALT and albumin levels.
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| first_indexed | 2024-04-12T13:21:59Z |
| format | Article |
| id | doaj.art-a2a1c4d60cf74b5284b6c04bacf31c43 |
| institution | Directory Open Access Journal |
| issn | 2663-4198 2663-4201 |
| language | English |
| last_indexed | 2024-04-12T13:21:59Z |
| publishDate | 2019-12-01 |
| publisher | University of Management and Technology |
| record_format | Article |
| series | Bioscientific Review |
| spelling | doaj.art-a2a1c4d60cf74b5284b6c04bacf31c432022-12-22T03:31:27ZengUniversity of Management and TechnologyBioscientific Review2663-41982663-42012019-12-011410.32350/BSR.0104.02The Correlation between Alpha-fetoprotein and Liver Function Tests Shahid Ali0Aqib Nazeer1Imran Tipu2University Institute of Medical Lab Technology, University of Lahore, Lahore, PakistanUniversity Institute of Medical Lab Technology, University of Lahore, Lahore, PakistanUniversity Institute of Medical Lab Technology, University of Lahore, Lahore, Pakistan Background Serum alpha-fetoprotein (AFP) level is a good indicator of important pathological stages in patients with chronic liver diseases. This study aims to investigate the alpha-fetoprotein level in male and female patients and to correlate it with other liver functions tests (LFTs), such as ALT, AST, total albumin and total protein. Methods A total of 100 patients within the age range 20-85 years who visited Shaukat Khanum Laboratory in Lahore were recruited for this study. Automated chemiluminicence microparticle immuno assay and immulite 2000 (CMIA, siemens USA) were used to measure serum AFP level. To measure serum ALT and AST, Architect 8200 kit (Abbott, USA) was used with a reference range of 0-50 U/L, according to the manufacturer’s protocols. Results Out of the total 100 samples (55 males, 45 females), 47 samples (47%) had normal AFP level (<5IU/l) and 53 samples (53%) had high AFP level (>5IU/l). A higher frequency of elevated AFP was observed in men at 60.38%. There was no significant correlation of AFP level with ALT (p= 0.38, r2= 0.002), T.P. (P. value= 0.7635 r2= 0.002) and albumin levels (p= 0.07, r2 =0.041). However, a significant correlation was found between AFP and AST levels (p= 0.02, r2= 0.15). Conclusion Our study found a higher AFP level in older population (>60) as compared to the younger people (20-40) and a higher frequency among males (60.38%) as compared to females (39.63%). It also found that AFP level significantly correlates with AST level but does not show any association with ALT and albumin levels. https://journals.umt.edu.pk/index.php/BSR/article/view/516Alpha-feotoproteinHepatocellular-carcinomaLiver function tests |
| spellingShingle | Shahid Ali Aqib Nazeer Imran Tipu The Correlation between Alpha-fetoprotein and Liver Function Tests Bioscientific Review Alpha-feotoprotein Hepatocellular-carcinoma Liver function tests |
| title | The Correlation between Alpha-fetoprotein and Liver Function Tests |
| title_full | The Correlation between Alpha-fetoprotein and Liver Function Tests |
| title_fullStr | The Correlation between Alpha-fetoprotein and Liver Function Tests |
| title_full_unstemmed | The Correlation between Alpha-fetoprotein and Liver Function Tests |
| title_short | The Correlation between Alpha-fetoprotein and Liver Function Tests |
| title_sort | correlation between alpha fetoprotein and liver function tests |
| topic | Alpha-feotoprotein Hepatocellular-carcinoma Liver function tests |
| url | https://journals.umt.edu.pk/index.php/BSR/article/view/516 |
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