Studying Effects of Gold Nanoparticle on Dose Enhancement in Megavoltage Radiation
Background: Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. Objective: The aim of this study is to understand characteristics of secondary electrons generated from inter...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2015-12-01
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| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | http://www.jbpe.org/Journal_OJS/JBPE/index.php/jbpe/article/view/327 |
| Summary: | Background: Gold nanoparticles are emerging as promising agents for cancer therapy
and are being investigated as drug carriers, photothermal agents, contrast agents
and radiosensitisers.
Objective: The aim of this study is to understand characteristics of secondary
electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function
of nanoparticle size and beam energy and thereby further understanding of GNPenhanced
radiotherapy.
Methods: Effective range, defection angle, dose deposition, energy, and interaction
processes of electrons produced from the interaction of x-rays with a GNP were
calculated by Monte Carlo simulations. The MCNPX code was used to simulate and
track electrons generated from 30 and 50 nm diameter GNP when it is irradiated with
a cobalt-60 and 6MV photon and electron beam in water.
Results: When a GNP was present, depending on beam types used, secondary electron
production increased by 10- to 2000-fold compared to absence of a GNP.
Conclusion: GNPs with larger diameters also contributed to more doses. |
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| ISSN: | 2251-7200 2251-7200 |