Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls
Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00720/full |
| _version_ | 1811192282458619904 |
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| author | Ali Shalash Mohamed Salama Mohamed Salama Marianne Makar Tamer Roushdy Hanan Hany Elrassas Wael Mohamed Wael Mohamed Mahmoud El-Balkimy Mohamed Abou Donia |
| author_facet | Ali Shalash Mohamed Salama Mohamed Salama Marianne Makar Tamer Roushdy Hanan Hany Elrassas Wael Mohamed Wael Mohamed Mahmoud El-Balkimy Mohamed Abou Donia |
| author_sort | Ali Shalash |
| collection | DOAJ |
| description | Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD. |
| first_indexed | 2024-04-11T23:50:01Z |
| format | Article |
| id | doaj.art-a2a3128d386540b1b531ba0476d8206e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T23:50:01Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a2a3128d386540b1b531ba0476d8206e2022-12-22T03:56:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-12-01810.3389/fneur.2017.00720320217Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and ControlsAli Shalash0Mohamed Salama1Mohamed Salama2Marianne Makar3Tamer Roushdy4Hanan Hany Elrassas5Wael Mohamed6Wael Mohamed7Mahmoud El-Balkimy8Mohamed Abou Donia9Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, EgyptMedical Experimental Research Centre (MERC), Faculty of Medicine, Mansoura University, Mansoura, EgyptFaculty of Medicine, Toxicology Department, Mansoura University, Mansoura, EgyptDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, EgyptFaculty of Medicine, Okasha Institute of Psychiatry, Ain Shams University, Cairo, EgyptFaculty of Medicine, Department of Clinical Pharmacology, Menoufia University, Shebin El-Kom, EgyptBasic Medical Science Department, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, MalaysiaDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, United StatesEarly diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD.http://journal.frontiersin.org/article/10.3389/fneur.2017.00720/fullautoantibodiesbiomarkersα synucleinParkinson’s diseaseAlzheimer’s disease |
| spellingShingle | Ali Shalash Mohamed Salama Mohamed Salama Marianne Makar Tamer Roushdy Hanan Hany Elrassas Wael Mohamed Wael Mohamed Mahmoud El-Balkimy Mohamed Abou Donia Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls Frontiers in Neurology autoantibodies biomarkers α synuclein Parkinson’s disease Alzheimer’s disease |
| title | Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls |
| title_full | Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls |
| title_fullStr | Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls |
| title_full_unstemmed | Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls |
| title_short | Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls |
| title_sort | elevated serum α synuclein autoantibodies in patients with parkinson s disease relative to alzheimer s disease and controls |
| topic | autoantibodies biomarkers α synuclein Parkinson’s disease Alzheimer’s disease |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00720/full |
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