Hyperactivation in the habenula as a link between depression and sleep disturbance
Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains un...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00826/full |
| _version_ | 1818509557742174208 |
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| author | Hidenori eAizawa Wanpeng eCui Kohichi eTanaka Hitoshi eOkamoto |
| author_facet | Hidenori eAizawa Wanpeng eCui Kohichi eTanaka Hitoshi eOkamoto |
| author_sort | Hidenori eAizawa |
| collection | DOAJ |
| description | Depression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains unknown.Habenula is an epithalamic structure regulating the activities of monoaminergic neurons in the brain stem. Since the imaging studies showed blood flow increase in the habenula of depressive patients, hyperactivation of the habenula has been implicated in the pathophysiology of the depression. Recent electrophysiological studies reported a novel role of the habenular structure in regulation of REM sleep. In this article, we propose possible cellular mechanisms which could elicit the hyperactivation of the habenular neurons and a hypothesis that dysfunction in the habenular circuit causes the behavioral and sleep disturbance in depression. Analysis of the animals with hyperactivated habenula would open the door to understand roles of the habenula in the heterogeneous symptoms such as reduced motor behavior and altered REM sleep in depression. |
| first_indexed | 2024-12-10T22:47:03Z |
| format | Article |
| id | doaj.art-a2a352c62f5840ba98c4001a1db720a5 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T22:47:03Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-a2a352c62f5840ba98c4001a1db720a52022-12-22T01:30:33ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-12-01710.3389/fnhum.2013.0082670852Hyperactivation in the habenula as a link between depression and sleep disturbanceHidenori eAizawa0Wanpeng eCui1Kohichi eTanaka2Hitoshi eOkamoto3Medical Research Institute, Tokyo Medical and Dental UniversityMedical Research Institute, Tokyo Medical and Dental UniversityMedical Research Institute, Tokyo Medical and Dental UniversityRIKEN Brain Science InstituteDepression occurs frequently with sleep disturbance such as insomnia. Sleep in depression is associated with disinhibition of the rapid eye movement (REM) sleep. Despite the coincidence of the depression and sleep disturbance, neural substrate for depressive behaviors and sleep regulation remains unknown.Habenula is an epithalamic structure regulating the activities of monoaminergic neurons in the brain stem. Since the imaging studies showed blood flow increase in the habenula of depressive patients, hyperactivation of the habenula has been implicated in the pathophysiology of the depression. Recent electrophysiological studies reported a novel role of the habenular structure in regulation of REM sleep. In this article, we propose possible cellular mechanisms which could elicit the hyperactivation of the habenular neurons and a hypothesis that dysfunction in the habenular circuit causes the behavioral and sleep disturbance in depression. Analysis of the animals with hyperactivated habenula would open the door to understand roles of the habenula in the heterogeneous symptoms such as reduced motor behavior and altered REM sleep in depression.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00826/fullDepressionGlutamatesHabenulaglutamate transportersmonoaminesrapid eye movement sleep (REMS) |
| spellingShingle | Hidenori eAizawa Wanpeng eCui Kohichi eTanaka Hitoshi eOkamoto Hyperactivation in the habenula as a link between depression and sleep disturbance Frontiers in Human Neuroscience Depression Glutamates Habenula glutamate transporters monoamines rapid eye movement sleep (REMS) |
| title | Hyperactivation in the habenula as a link between depression and sleep disturbance |
| title_full | Hyperactivation in the habenula as a link between depression and sleep disturbance |
| title_fullStr | Hyperactivation in the habenula as a link between depression and sleep disturbance |
| title_full_unstemmed | Hyperactivation in the habenula as a link between depression and sleep disturbance |
| title_short | Hyperactivation in the habenula as a link between depression and sleep disturbance |
| title_sort | hyperactivation in the habenula as a link between depression and sleep disturbance |
| topic | Depression Glutamates Habenula glutamate transporters monoamines rapid eye movement sleep (REMS) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00826/full |
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