Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice

Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice

Mu opioid receptor (MOR) activation facilitates reward processing and reduces pain, and brain networks underlying these effects are under intense investigation. Mice lacking the MOR gene (MOR KO mice) show lower drug and social reward, enhanced pain sensitivity and altered emotional responses. Our p...

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Bibliographic Details
Main Authors: Md Taufiq Nasseef, Gabriel A. Devenyi, Anna E. Mechling, Laura-Adela Harsan, M. Mallar Chakravarty, Brigitte Lina Kieffer, Emmanuel Darcq
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Psychiatry
Subjects:
MRI
in-vivo
mice
structural change
mu opioid receptor
anatomical
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00643/full

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