Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03253-8 |
| _version_ | 1811291031362076672 |
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| author | Urša Šušnjar Neva Škrabar Anna-Leigh Brown Yasmine Abbassi Hemali Phatnani NYGC ALS Consortium Andrea Cortese Cristina Cereda Enrico Bugiardini Rosanna Cardani Giovanni Meola Michela Ripolone Maurizio Moggio Maurizio Romano Maria Secrier Pietro Fratta Emanuele Buratti |
| author_facet | Urša Šušnjar Neva Škrabar Anna-Leigh Brown Yasmine Abbassi Hemali Phatnani NYGC ALS Consortium Andrea Cortese Cristina Cereda Enrico Bugiardini Rosanna Cardani Giovanni Meola Michela Ripolone Maurizio Moggio Maurizio Romano Maria Secrier Pietro Fratta Emanuele Buratti |
| author_sort | Urša Šušnjar |
| collection | DOAJ |
| description | The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development. |
| first_indexed | 2024-04-13T04:23:15Z |
| format | Article |
| id | doaj.art-a2a3e5c080324289af930097b013f70e |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T04:23:15Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a2a3e5c080324289af930097b013f70e2022-12-22T03:02:39ZengNature PortfolioCommunications Biology2399-36422022-04-015111710.1038/s42003-022-03253-8Cell environment shapes TDP-43 function with implications in neuronal and muscle diseaseUrša Šušnjar0Neva Škrabar1Anna-Leigh Brown2Yasmine Abbassi3Hemali Phatnani4NYGC ALS ConsortiumAndrea Cortese5Cristina Cereda6Enrico Bugiardini7Rosanna Cardani8Giovanni Meola9Michela Ripolone10Maurizio Moggio11Maurizio Romano12Maria Secrier13Pietro Fratta14Emanuele Buratti15Molecular Pathology Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB)Tumour Virology Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB)Department of Neuromuscular Diseases, UCL Queen Square Institute of NeurologyMolecular Pathology Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB)Center for Genomics of Neurodegenerative Disease, New York Genome CenterDepartment of Neuromuscular Diseases, UCL Queen Square Institute of NeurologyGenomic and post-Genomic Unit, IRCCS Mondino FoundationDepartment of Neuromuscular Diseases, UCL Queen Square Institute of NeurologyBioCor Biobank, UOC SMEL-1 of Clinical Pathology, IRCCS-Policlinico San DonatoDepartment of Biomedical Sciences for Health, University of MilanNeuromuscular and Rare Diseases Unit, Department of Neuroscience, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoNeuromuscular and Rare Diseases Unit, Department of Neuroscience, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Life Sciences, University of TriesteUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College LondonDepartment of Neuromuscular Diseases, UCL Queen Square Institute of NeurologyMolecular Pathology Lab, International Centre for Genetic Engineering and Biotechnology (ICGEB)The aetiology of the TDP-43 aggregation manifest itself in the muscle and neuronal cells. Here authors show cell-type characteristic functions of TDP43, reflected in aberrant splicing, likely contributing to disease development.https://doi.org/10.1038/s42003-022-03253-8 |
| spellingShingle | Urša Šušnjar Neva Škrabar Anna-Leigh Brown Yasmine Abbassi Hemali Phatnani NYGC ALS Consortium Andrea Cortese Cristina Cereda Enrico Bugiardini Rosanna Cardani Giovanni Meola Michela Ripolone Maurizio Moggio Maurizio Romano Maria Secrier Pietro Fratta Emanuele Buratti Cell environment shapes TDP-43 function with implications in neuronal and muscle disease Communications Biology |
| title | Cell environment shapes TDP-43 function with implications in neuronal and muscle disease |
| title_full | Cell environment shapes TDP-43 function with implications in neuronal and muscle disease |
| title_fullStr | Cell environment shapes TDP-43 function with implications in neuronal and muscle disease |
| title_full_unstemmed | Cell environment shapes TDP-43 function with implications in neuronal and muscle disease |
| title_short | Cell environment shapes TDP-43 function with implications in neuronal and muscle disease |
| title_sort | cell environment shapes tdp 43 function with implications in neuronal and muscle disease |
| url | https://doi.org/10.1038/s42003-022-03253-8 |
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