Moonlighting Proteins at the Candidal Cell Surface
The cell wall in <i>Candida albicans</i> is not only a tight protective envelope but also a point of contact with the human host that provides a dynamic response to the constantly changing environment in infection niches. Particularly important roles are attributed to proteins exposed at...
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MDPI AG
2020-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/7/1046 |
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| author | Dorota Satala Justyna Karkowska-Kuleta Aleksandra Zelazna Maria Rapala-Kozik Andrzej Kozik |
| author_facet | Dorota Satala Justyna Karkowska-Kuleta Aleksandra Zelazna Maria Rapala-Kozik Andrzej Kozik |
| author_sort | Dorota Satala |
| collection | DOAJ |
| description | The cell wall in <i>Candida albicans</i> is not only a tight protective envelope but also a point of contact with the human host that provides a dynamic response to the constantly changing environment in infection niches. Particularly important roles are attributed to proteins exposed at the fungal cell surface. These include proteins that are stably and covalently bound to the cell wall or cell membrane and those that are more loosely attached. Interestingly in this regard, numerous loosely attached proteins belong to the class of “moonlighting proteins” that are originally intracellular and that perform essentially different functions in addition to their primary housekeeping roles. These proteins also demonstrate unpredicted interactions with non-canonical partners at an a priori unexpected extracellular location, achieved via non-classical secretion routes. Acting both individually and collectively, the moonlighting proteins contribute to candidal virulence and pathogenicity through their involvement in mechanisms critical for successful host colonization and infection, such as the adhesion to host cells, interactions with plasma homeostatic proteolytic cascades, responses to stress conditions and molecular mimicry. The documented knowledge of the roles of these proteins in <i>C. albicans</i> pathogenicity has utility for assisting the design of new therapeutic, diagnostic and preventive strategies against candidiasis. |
| first_indexed | 2024-03-10T18:29:53Z |
| format | Article |
| id | doaj.art-a2a5b5957a7242dea45256827d16b17b |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:29:53Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a2a5b5957a7242dea45256827d16b17b2023-11-20T06:45:03ZengMDPI AGMicroorganisms2076-26072020-07-0187104610.3390/microorganisms8071046Moonlighting Proteins at the Candidal Cell SurfaceDorota Satala0Justyna Karkowska-Kuleta1Aleksandra Zelazna2Maria Rapala-Kozik3Andrzej Kozik4Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7, 30-387 Krakow, PolandDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7, 30-387 Krakow, PolandDepartment of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7, 30-387 Krakow, PolandDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7, 30-387 Krakow, PolandDepartment of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Gronostajowa 7, 30-387 Krakow, PolandThe cell wall in <i>Candida albicans</i> is not only a tight protective envelope but also a point of contact with the human host that provides a dynamic response to the constantly changing environment in infection niches. Particularly important roles are attributed to proteins exposed at the fungal cell surface. These include proteins that are stably and covalently bound to the cell wall or cell membrane and those that are more loosely attached. Interestingly in this regard, numerous loosely attached proteins belong to the class of “moonlighting proteins” that are originally intracellular and that perform essentially different functions in addition to their primary housekeeping roles. These proteins also demonstrate unpredicted interactions with non-canonical partners at an a priori unexpected extracellular location, achieved via non-classical secretion routes. Acting both individually and collectively, the moonlighting proteins contribute to candidal virulence and pathogenicity through their involvement in mechanisms critical for successful host colonization and infection, such as the adhesion to host cells, interactions with plasma homeostatic proteolytic cascades, responses to stress conditions and molecular mimicry. The documented knowledge of the roles of these proteins in <i>C. albicans</i> pathogenicity has utility for assisting the design of new therapeutic, diagnostic and preventive strategies against candidiasis.https://www.mdpi.com/2076-2607/8/7/1046<i>Candida</i> yeastcell wallprotein moonlightingnon-classical secretionadhesionplasminogen |
| spellingShingle | Dorota Satala Justyna Karkowska-Kuleta Aleksandra Zelazna Maria Rapala-Kozik Andrzej Kozik Moonlighting Proteins at the Candidal Cell Surface Microorganisms <i>Candida</i> yeast cell wall protein moonlighting non-classical secretion adhesion plasminogen |
| title | Moonlighting Proteins at the Candidal Cell Surface |
| title_full | Moonlighting Proteins at the Candidal Cell Surface |
| title_fullStr | Moonlighting Proteins at the Candidal Cell Surface |
| title_full_unstemmed | Moonlighting Proteins at the Candidal Cell Surface |
| title_short | Moonlighting Proteins at the Candidal Cell Surface |
| title_sort | moonlighting proteins at the candidal cell surface |
| topic | <i>Candida</i> yeast cell wall protein moonlighting non-classical secretion adhesion plasminogen |
| url | https://www.mdpi.com/2076-2607/8/7/1046 |
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