Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis
Background: The acute phase response is a major pathophysiologic phenomena that accompanies inflammation whether acute or chronic. The complements 3 (C3), complement4 (C4) and C-reactive protein (CRP) are positive acute phase proteins (+ve APPs) their production is increased by hepatocyte in osteoar...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2008-10-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1266 |
| _version_ | 1797368746219667456 |
|---|---|
| author | Kismat M. Turki |
| author_facet | Kismat M. Turki |
| author_sort | Kismat M. Turki |
| collection | DOAJ |
| description | Background: The acute phase response is a major pathophysiologic phenomena that accompanies inflammation whether acute or chronic. The complements 3 (C3), complement4
(C4) and C-reactive protein (CRP) are positive acute phase proteins (+ve APPs) their production is increased by hepatocyte in osteoarthritis (OA). Chloroquine (CQ) which is a diprotic weak base traditionally used to treat malaria.Todate, the phosphate salt of CQ is used to decrease +ve APPs.
Objective: To evaluate the role of chloroquine phosphate on acute phase proteins C3, C4 and Creactive protein in patients with knee OA.
Subjects and methods :A total of seventy four patients (45 female and 29male) were selected randomly from the outpatients clinic in Baghdad teaching Hospital, Medical City, Baghdad
suffering from knee OA were treated with oral dosage form of CQP for one month, twice daily. The levels of C3, C4 and C-reactive protein in serum of all patients were measured before and after treatment using ELISA technique.The serum level of C3, C4 and C-RP were calculated as mean ± standard error of mean (SEM); paired t-test was used; S= significant, P value < 0.05
Results :The levels of C3, C4 and C-RP were significantly reduced (P< 0.05) in serum of all patients after treatment with CQP for one month.
Conclusion :CQP is a disease modifying anti rheumatic drug (DMARD) used for patients suffering from KOA in order to reduce their C3, C4 and C-RP value and improves the disease
status. |
| first_indexed | 2024-03-08T17:37:11Z |
| format | Article |
| id | doaj.art-a2a71d62b6aa42db9602058274addadc |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:37:11Z |
| publishDate | 2008-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-a2a71d62b6aa42db9602058274addadc2024-01-02T11:45:11ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572008-10-0150310.32007/1266%g400-402Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritisKismat M. Turki0٭Baghdad University, College of Medicine, Department of Physiological Chemistry.Background: The acute phase response is a major pathophysiologic phenomena that accompanies inflammation whether acute or chronic. The complements 3 (C3), complement4 (C4) and C-reactive protein (CRP) are positive acute phase proteins (+ve APPs) their production is increased by hepatocyte in osteoarthritis (OA). Chloroquine (CQ) which is a diprotic weak base traditionally used to treat malaria.Todate, the phosphate salt of CQ is used to decrease +ve APPs. Objective: To evaluate the role of chloroquine phosphate on acute phase proteins C3, C4 and Creactive protein in patients with knee OA. Subjects and methods :A total of seventy four patients (45 female and 29male) were selected randomly from the outpatients clinic in Baghdad teaching Hospital, Medical City, Baghdad suffering from knee OA were treated with oral dosage form of CQP for one month, twice daily. The levels of C3, C4 and C-reactive protein in serum of all patients were measured before and after treatment using ELISA technique.The serum level of C3, C4 and C-RP were calculated as mean ± standard error of mean (SEM); paired t-test was used; S= significant, P value < 0.05 Results :The levels of C3, C4 and C-RP were significantly reduced (P< 0.05) in serum of all patients after treatment with CQP for one month. Conclusion :CQP is a disease modifying anti rheumatic drug (DMARD) used for patients suffering from KOA in order to reduce their C3, C4 and C-RP value and improves the disease status.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1266Chloroquine phosphate, acute phase protein, knee osteoarthritis, C-reactive protein, and complement. |
| spellingShingle | Kismat M. Turki Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis مجلة كلية الطب Chloroquine phosphate, acute phase protein, knee osteoarthritis, C-reactive protein, and complement. |
| title | Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis |
| title_full | Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis |
| title_fullStr | Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis |
| title_full_unstemmed | Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis |
| title_short | Role of Chloroquine phosphate on Acute phase reactant in patients with knee osteoarthritis |
| title_sort | role of chloroquine phosphate on acute phase reactant in patients with knee osteoarthritis |
| topic | Chloroquine phosphate, acute phase protein, knee osteoarthritis, C-reactive protein, and complement. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1266 |
| work_keys_str_mv | AT kismatmturki roleofchloroquinephosphateonacutephasereactantinpatientswithkneeosteoarthritis |