Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma
Background: Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by abundant immunocytes infiltration. The impact of guanosine triphosphatases (GTPases) of immunity-associated proteins (GIMAPs) on the tumor immune microenvironment (TIME) and prognos...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-11-01
|
| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811308 |
| _version_ | 1797400737235337216 |
|---|---|
| author | Mengjiao Zhang Xu Zhang Jing Hou Xuemei Liang Ming Zhang |
| author_facet | Mengjiao Zhang Xu Zhang Jing Hou Xuemei Liang Ming Zhang |
| author_sort | Mengjiao Zhang |
| collection | DOAJ |
| description | Background: Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by abundant immunocytes infiltration. The impact of guanosine triphosphatases (GTPases) of immunity-associated proteins (GIMAPs) on the tumor immune microenvironment (TIME) and prognosis of ccRCC is unclear. Methods: The expression of GIMAPs in ccRCC was determined through multiple datasets (ONCOMINE, TCGA and UALCAN). The relationship between GIMAP family members was analyzed through Spearman correlation analysis. The interaction among the GIMAPs protein was analyzed using STRING. Prognostic values of GIMAPs were evaluated by Survival analysis, Lasso and Cox regression analysis; Prognostic risk model and nomogram were constructed. The correlation between GIMAPs and TIME was explored using TIMER, Cibersort and Pearson correlation analysis. Gene set enrichment analysis (GSEA) was performed to discuss their function and mechanism in ccRCC. Results: GIMAPs were over-expressed in ccRCC and significantly related to overall survival (OS) of the patients. GIMAPs were positively correlated with each other, the risk model based on GIMAPs had good prognostic value in ccRCC. GIMAPs mainly expressed in TIME and were associated with abundant immunocytic infiltration in ccRCC, the risk model also had close correlation with TIME. Our results showed GIMAPs may affect the development of ccRCC by regulating the amount and antitumor activity of immunocytes in TIME. Conclusions: GIMAPs were over-expressed in ccRCC, and their expression levels were significantly related to the OS of patients and immunocytic infiltration in TIME. GIMAPs are potential therapeutic targets and prognostic biomarkers for ccRCC. |
| first_indexed | 2024-03-09T01:59:52Z |
| format | Article |
| id | doaj.art-a2a883e06d654ec79ce9bd3dd0688d37 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-09T01:59:52Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-a2a883e06d654ec79ce9bd3dd0688d372023-12-08T07:49:20ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-11-01281130810.31083/j.fbl2811308S2768-6701(23)00950-4Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell CarcinomaMengjiao Zhang0Xu Zhang1Jing Hou2Xuemei Liang3Ming Zhang4Department of Geriatric Medicine, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, 646000 Luzhou, Sichuan, ChinaBackground: Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by abundant immunocytes infiltration. The impact of guanosine triphosphatases (GTPases) of immunity-associated proteins (GIMAPs) on the tumor immune microenvironment (TIME) and prognosis of ccRCC is unclear. Methods: The expression of GIMAPs in ccRCC was determined through multiple datasets (ONCOMINE, TCGA and UALCAN). The relationship between GIMAP family members was analyzed through Spearman correlation analysis. The interaction among the GIMAPs protein was analyzed using STRING. Prognostic values of GIMAPs were evaluated by Survival analysis, Lasso and Cox regression analysis; Prognostic risk model and nomogram were constructed. The correlation between GIMAPs and TIME was explored using TIMER, Cibersort and Pearson correlation analysis. Gene set enrichment analysis (GSEA) was performed to discuss their function and mechanism in ccRCC. Results: GIMAPs were over-expressed in ccRCC and significantly related to overall survival (OS) of the patients. GIMAPs were positively correlated with each other, the risk model based on GIMAPs had good prognostic value in ccRCC. GIMAPs mainly expressed in TIME and were associated with abundant immunocytic infiltration in ccRCC, the risk model also had close correlation with TIME. Our results showed GIMAPs may affect the development of ccRCC by regulating the amount and antitumor activity of immunocytes in TIME. Conclusions: GIMAPs were over-expressed in ccRCC, and their expression levels were significantly related to the OS of patients and immunocytic infiltration in TIME. GIMAPs are potential therapeutic targets and prognostic biomarkers for ccRCC.https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811308gimapsclear cell renal cell carcinomatumor immune microenvironmentprognosisbiomarker |
| spellingShingle | Mengjiao Zhang Xu Zhang Jing Hou Xuemei Liang Ming Zhang Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma Frontiers in Bioscience-Landmark gimaps clear cell renal cell carcinoma tumor immune microenvironment prognosis biomarker |
| title | Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma |
| title_full | Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma |
| title_fullStr | Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma |
| title_full_unstemmed | Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma |
| title_short | Prognostic and Immune Infiltration Signatures of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma |
| title_sort | prognostic and immune infiltration signatures of gimap family genes in clear cell renal cell carcinoma |
| topic | gimaps clear cell renal cell carcinoma tumor immune microenvironment prognosis biomarker |
| url | https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811308 |
| work_keys_str_mv | AT mengjiaozhang prognosticandimmuneinfiltrationsignaturesofgimapfamilygenesinclearcellrenalcellcarcinoma AT xuzhang prognosticandimmuneinfiltrationsignaturesofgimapfamilygenesinclearcellrenalcellcarcinoma AT jinghou prognosticandimmuneinfiltrationsignaturesofgimapfamilygenesinclearcellrenalcellcarcinoma AT xuemeiliang prognosticandimmuneinfiltrationsignaturesofgimapfamilygenesinclearcellrenalcellcarcinoma AT mingzhang prognosticandimmuneinfiltrationsignaturesofgimapfamilygenesinclearcellrenalcellcarcinoma |