COMMD proteins function and their regulating roles in tumors
The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1067234/full |
| _version_ | 1828053620746092544 |
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| author | Guangqiang You Chen Zhou Lei Wang Zefeng Liu He Fang Xiaoxao Yao Xuewen Zhang |
| author_facet | Guangqiang You Chen Zhou Lei Wang Zefeng Liu He Fang Xiaoxao Yao Xuewen Zhang |
| author_sort | Guangqiang You |
| collection | DOAJ |
| description | The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial. |
| first_indexed | 2024-04-10T20:10:27Z |
| format | Article |
| id | doaj.art-a2a8ca2e60e64576b775f39d14a7b03a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T20:10:27Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a2a8ca2e60e64576b775f39d14a7b03a2023-01-26T13:55:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011310.3389/fonc.2023.10672341067234COMMD proteins function and their regulating roles in tumorsGuangqiang You0Chen Zhou1Lei Wang2Zefeng Liu3He Fang4Xiaoxao Yao5Xuewen Zhang6Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of General Affairs, First Hospital of Jilin University (the Eastern Division), Jilin University, Changchun, ChinaDepartment of Pediatric Neurology, First Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Jilin University, Jilin University, Changchun, ChinaThe COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial.https://www.frontiersin.org/articles/10.3389/fonc.2023.1067234/fullCOMMDcancercopper homeostasisendosomal sortingion transportNF-κB |
| spellingShingle | Guangqiang You Chen Zhou Lei Wang Zefeng Liu He Fang Xiaoxao Yao Xuewen Zhang COMMD proteins function and their regulating roles in tumors Frontiers in Oncology COMMD cancer copper homeostasis endosomal sorting ion transport NF-κB |
| title | COMMD proteins function and their regulating roles in tumors |
| title_full | COMMD proteins function and their regulating roles in tumors |
| title_fullStr | COMMD proteins function and their regulating roles in tumors |
| title_full_unstemmed | COMMD proteins function and their regulating roles in tumors |
| title_short | COMMD proteins function and their regulating roles in tumors |
| title_sort | commd proteins function and their regulating roles in tumors |
| topic | COMMD cancer copper homeostasis endosomal sorting ion transport NF-κB |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1067234/full |
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