Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes
Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of neurons and glia from central nervous system...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.843794/full |
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| author | Ryan F. Leung Ryan F. Leung Ankita M. George Enola M. Roussel Maree C. Faux Maree C. Faux Maree C. Faux Jeffrey T. Wigle Jeffrey T. Wigle David D. Eisenstat David D. Eisenstat David D. Eisenstat David D. Eisenstat |
| author_facet | Ryan F. Leung Ryan F. Leung Ankita M. George Enola M. Roussel Maree C. Faux Maree C. Faux Maree C. Faux Jeffrey T. Wigle Jeffrey T. Wigle David D. Eisenstat David D. Eisenstat David D. Eisenstat David D. Eisenstat |
| author_sort | Ryan F. Leung |
| collection | DOAJ |
| description | Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of neurons and glia from central nervous system (CNS) progenitor cells. Moreover, cell fate decisions, differentiation and migration of these committed CNS progenitors are controlled by the gene regulatory networks that are regulated by various homeodomain-containing transcription factors, including but not limited to those of the Pax (paired), Nkx, Otx (orthodenticle), Gsx/Gsh (genetic screened), and Dlx (distal-less) homeobox gene families. This comprehensive review outlines the integral role of key homeobox transcription factors and their target genes on forebrain development, focused primarily on the telencephalon. Furthermore, links of these transcription factors to human diseases, such as neurodevelopmental disorders and brain tumors are provided. |
| first_indexed | 2024-12-12T23:21:04Z |
| format | Article |
| id | doaj.art-a2ab1209f1f84256818f9f22cae93f25 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T23:21:04Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a2ab1209f1f84256818f9f22cae93f252022-12-22T00:08:16ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.843794843794Genetic Regulation of Vertebrate Forebrain Development by Homeobox GenesRyan F. Leung0Ryan F. Leung1Ankita M. George2Enola M. Roussel3Maree C. Faux4Maree C. Faux5Maree C. Faux6Jeffrey T. Wigle7Jeffrey T. Wigle8David D. Eisenstat9David D. Eisenstat10David D. Eisenstat11David D. Eisenstat12Murdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Parkville, VIC, AustraliaMurdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville, VIC, AustraliaMurdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville, VIC, AustraliaMurdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Parkville, VIC, AustraliaDepartment of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, AustraliaDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, CanadaMurdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville, VIC, AustraliaDepartment of Paediatrics, University of Melbourne, Parkville, VIC, AustraliaDepartment of Medical Genetics, University of Alberta, Edmonton, AB, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB, CanadaForebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of neurons and glia from central nervous system (CNS) progenitor cells. Moreover, cell fate decisions, differentiation and migration of these committed CNS progenitors are controlled by the gene regulatory networks that are regulated by various homeodomain-containing transcription factors, including but not limited to those of the Pax (paired), Nkx, Otx (orthodenticle), Gsx/Gsh (genetic screened), and Dlx (distal-less) homeobox gene families. This comprehensive review outlines the integral role of key homeobox transcription factors and their target genes on forebrain development, focused primarily on the telencephalon. Furthermore, links of these transcription factors to human diseases, such as neurodevelopmental disorders and brain tumors are provided.https://www.frontiersin.org/articles/10.3389/fnins.2022.843794/fullforebraindevelopmenthomeoboxbHLH factorforkhead (Fkh) transcription factorsDNA binding domain |
| spellingShingle | Ryan F. Leung Ryan F. Leung Ankita M. George Enola M. Roussel Maree C. Faux Maree C. Faux Maree C. Faux Jeffrey T. Wigle Jeffrey T. Wigle David D. Eisenstat David D. Eisenstat David D. Eisenstat David D. Eisenstat Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes Frontiers in Neuroscience forebrain development homeobox bHLH factor forkhead (Fkh) transcription factors DNA binding domain |
| title | Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes |
| title_full | Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes |
| title_fullStr | Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes |
| title_full_unstemmed | Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes |
| title_short | Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes |
| title_sort | genetic regulation of vertebrate forebrain development by homeobox genes |
| topic | forebrain development homeobox bHLH factor forkhead (Fkh) transcription factors DNA binding domain |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.843794/full |
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