Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core
A possible inhibitor of proteases, which contains an indole core and an aromatic polar acetylene, was designed and synthesized. This indole derivative has a molecular architecture kindred to biologically relevant species and was obtained through five synthetic steps with an overall yield of 37% from...
Main Authors: | Marco A. Almaraz-Girón, Ernesto Calderón-Jaimes, Adrián Sánchez Carrillo, Erik Díaz-Cervantes, Edith Castañón Alonso, Alejandro Islas-Jácome, Armando Domínguez-Ortiz, Sandra L. Castañón-Alonso |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/13/3817 |
Similar Items
-
Synthesis of New <i>bis</i>-furanyl-pyrrolo[3,4-<i>b</i>]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M<sup>Pro</sup>) from SARS-CoV-2
by: Ivette Morales-Salazar, et al.
Published: (2021-11-01) -
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
by: Piyush Kashyap, et al.
Published: (2022-09-01) -
Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from <i>Nuphar lutea</i>
by: Kamran Waidha, et al.
Published: (2021-08-01) -
Scaffold Hopping of α-Rubromycin Enables Direct Access to FDA-Approved Cromoglicic Acid as a SARS-CoV-2 M<sup>Pro</sup> Inhibitor
by: Hani A. Alhadrami, et al.
Published: (2021-06-01) -
Ensemble Docking Coupled to Linear Interaction Energy Calculations for Identification of Coronavirus Main Protease (3CL<sup>pro</sup>) Non-Covalent Small-Molecule Inhibitors
by: Marko Jukič, et al.
Published: (2020-12-01)