“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review
Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/6/1677 |
| _version_ | 1797593063827177472 |
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| author | Nimeet Desai Dhwani Rana Shreya Pande Sagar Salave Jyotsnendu Giri Derajram Benival Nagavendra Kommineni |
| author_facet | Nimeet Desai Dhwani Rana Shreya Pande Sagar Salave Jyotsnendu Giri Derajram Benival Nagavendra Kommineni |
| author_sort | Nimeet Desai |
| collection | DOAJ |
| description | Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics. |
| first_indexed | 2024-03-11T02:03:26Z |
| format | Article |
| id | doaj.art-a2ae2061d203407082088e86b3a1ba4c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T02:03:26Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a2ae2061d203407082088e86b3a1ba4c2023-11-18T12:04:54ZengMDPI AGPharmaceutics1999-49232023-06-01156167710.3390/pharmaceutics15061677“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive ReviewNimeet Desai0Dhwani Rana1Shreya Pande2Sagar Salave3Jyotsnendu Giri4Derajram Benival5Nagavendra Kommineni6Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, IndiaCenter for Biomedical Research, Population Council, New York, NY 10065, USAAchieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics.https://www.mdpi.com/1999-4923/15/6/1677cancertheranosticsnanoparticlescell membranemembrane coatingtumor targeting |
| spellingShingle | Nimeet Desai Dhwani Rana Shreya Pande Sagar Salave Jyotsnendu Giri Derajram Benival Nagavendra Kommineni “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review Pharmaceutics cancer theranostics nanoparticles cell membrane membrane coating tumor targeting |
| title | “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review |
| title_full | “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review |
| title_fullStr | “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review |
| title_full_unstemmed | “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review |
| title_short | “Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review |
| title_sort | bioinspired membrane coated nanosystems in cancer theranostics a comprehensive review |
| topic | cancer theranostics nanoparticles cell membrane membrane coating tumor targeting |
| url | https://www.mdpi.com/1999-4923/15/6/1677 |
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