Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population

Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population

Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic populations. We aimed to investigate th...

Bibliográfalaš dieđut
Váldodahkkit:	Xin-Hui Khoo, Shin Yee Wong, Nik Razima Wan Ibrahim, Ruey Terng Ng, Kee Seang Chew, Way Seah Lee, Zhi Qin Wong, Raja Affend Raja Ali, Shahreedhan Shahrani, Alex Hwong-Ruey Leow, Ida Normiha Hilmi
Materiálatiipa:	Artihkal
Giella:	English
Almmustuhtton:	Frontiers Media S.A. 2022-08-01
Ráidu:	Frontiers in Medicine
Fáttát:	NUDT15 inflammatory bowel disease leukopenia genetic polymorphism thiopurines
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fmed.2022.880937/full

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