CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice

CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice

Cranial neural crest cells (CNCCs), identified by expression of transcription factor Sox9, migrate to the first branchial arch and undergo proliferation and differentiation to form the cartilage and bone structures of the orofacial region, including the palatal bone. Sox9 promotes osteogenic differe...

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Bibliographic Details
Main Authors: Nanne Verheijen, Christiaan M. Suttorp, René E. M. van Rheden, Raymond F. Regan, Maria P. A. C. Helmich, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
embryology
cranial neural crest cells
Sox9
osteogenesis
palatogenesis
CXCL12-CXCR4
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00771/full

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