Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability

Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability

Summary: The yeast Mre11-Rad50-Xrs2 (MRX) complex has structural, signaling, and catalytic functions in the response to DNA damage. Xrs2, the eukaryotic-specific component of the complex, is required for nuclear import of Mre11 and Rad50 and to recruit the Tel1 kinase to damage sites. We show that n...

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Bibliographic Details
Main Authors: Julyun Oh, So Jung Lee, Rodney Rothstein, Lorraine S. Symington
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316061

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