Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes
Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/19/10/2890 |
| _version_ | 1811233228454887424 |
|---|---|
| author | Elias J. Sayour Hector R. Mendez-Gomez Duane A. Mitchell |
| author_facet | Elias J. Sayour Hector R. Mendez-Gomez Duane A. Mitchell |
| author_sort | Elias J. Sayour |
| collection | DOAJ |
| description | Cancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines. |
| first_indexed | 2024-04-12T11:18:06Z |
| format | Article |
| id | doaj.art-a2b4718f6d484e0981b80b665503cd23 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T11:18:06Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a2b4718f6d484e0981b80b665503cd232022-12-22T03:35:27ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-011910289010.3390/ijms19102890ijms19102890Cancer Vaccine Immunotherapy with RNA-Loaded LiposomesElias J. Sayour0Hector R. Mendez-Gomez1Duane A. Mitchell2Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida Brain Tumor Immunotherapy Program, Lilian S. Wells Department of Neurosurgery, 1149 South Newell Drive, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USAPreston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida Brain Tumor Immunotherapy Program, Lilian S. Wells Department of Neurosurgery, 1149 South Newell Drive, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USAPreston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida Brain Tumor Immunotherapy Program, Lilian S. Wells Department of Neurosurgery, 1149 South Newell Drive, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USACancer vaccines may be harnessed to incite immunity against poorly immunogenic tumors, however they have failed in therapeutic settings. Poor antigenicity coupled with systemic and intratumoral immune suppression have been significant drawbacks. RNA encoding for tumor associated or specific epitopes can serve as a more immunogenic and expeditious trigger of anti-tumor immunity. RNA stimulates innate immunity through toll like receptor stimulation producing type I interferon, and it mediates potent adaptive responses. Since RNA is inherently unstable, delivery systems have been developed to protect and deliver it to intended targets in vivo. In this review, we discuss liposomes as RNA delivery vehicles and their role as cancer vaccines.http://www.mdpi.com/1422-0067/19/10/2890immunotherapyliposomesRNAcancer vaccines |
| spellingShingle | Elias J. Sayour Hector R. Mendez-Gomez Duane A. Mitchell Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes International Journal of Molecular Sciences immunotherapy liposomes RNA cancer vaccines |
| title | Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes |
| title_full | Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes |
| title_fullStr | Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes |
| title_full_unstemmed | Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes |
| title_short | Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes |
| title_sort | cancer vaccine immunotherapy with rna loaded liposomes |
| topic | immunotherapy liposomes RNA cancer vaccines |
| url | http://www.mdpi.com/1422-0067/19/10/2890 |
| work_keys_str_mv | AT eliasjsayour cancervaccineimmunotherapywithrnaloadedliposomes AT hectorrmendezgomez cancervaccineimmunotherapywithrnaloadedliposomes AT duaneamitchell cancervaccineimmunotherapywithrnaloadedliposomes |