Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage

Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage

Background: Rosmarinic acid (RA) has biological and pharmaceutical properties and shows hepatoprotective potential. However, the hepatoprotective mechanism of RA needs to be further elucidated in vivo and in vitro. Objective: This study was aimed to evaluate the protective effect of RA on carbon tet...

Full description

Bibliographic Details
Main Authors:	Yue-hong Lu, Yue Hong, Tian-yang Zhang, You-xia Chen, Zhao-jun Wei, Chun-yan Gao
Format:	Article
Language:	English
Published:	Swedish Nutrition Foundation 2022-11-01
Series:	Food & Nutrition Research
Subjects:	rosmarinic acid hepatoprotective effect nrf2 pathway oxidative stress inflammation
Online Access:	https://foodandnutritionresearch.net/index.php/fnr/article/view/8359/15005

Similar Items

Rosmarinic Acid, the Main Effective Constituent of Orthosiphon stamineus, Inhibits Intestinal Epithelial Apoptosis Via Regulation of the Nrf2 Pathway in Mice
by: Xuan Cai, et al.
Published: (2019-08-01)

Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway
by: Yifei Xiang, et al.
Published: (2022-11-01)

Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome
by: Sonia Marinho, et al.
Published: (2021-01-01)

Hepatoprotective Effects of Rosmarinic Acid on Ovalbumin-Induced Intestinal Food Allergy Mouse Model
by: Binmei Jia, et al.
Published: (2023-01-01)

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases
by: Chunxu Luo, et al.
Published: (2020-02-01)

Cyanidin-3-glucoside protects liver from oxidative damage through AMPK/Nrf2 mediated signaling pathway in vivo and in vitro
by: Liang Yu, et al.
Published: (2020-10-01)

The anti-inflammatory and anti-glycative effects of rosmarinic acid in the livers of type 1 diabetic mice
by: Wen Yu-Ju, et al.
Published: (2017-09-01)

Effect of Purple Sweet Potato Using Different Cooking Methods on Cytoprotection against Ethanol-Induced Oxidative Damage through Nrf2 Activation in HepG2 Cells
by: Dagyeong Kim, et al.
Published: (2023-08-01)

Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury
by: Jianbin Min, et al.
Published: (2018-09-01)

Hepatoprotection by Traditional Essence of Ginseng against Carbon Tetrachloride—Induced Liver Damage
by: Yi-Ju Hsu, et al.
Published: (2020-10-01)

Hepatoprotective Effect of Sodium Molybdate on Carbon Tetrachloride-induced Liver Damage in Rats
by: Haeri Rohani A, et al.
Published: (2011-06-01)

Hepatoprotective effect of polysaccharide isolated from Sonneratia apetala fruits on acetaminophen-induced liver injury mice
by: Jingjing Liu, et al.
Published: (2021-11-01)

Protective effects of rosmarinic acid on sepsis-induced DNA damage in the liver of Wistar albino rats
by: Hatice Gul Goktas, et al.
Published: (2015-06-01)

Hepatoprotective effect of esculetin on ethanol-induced liver injury in human HepG2 cells and C57BL/6J mice
by: Jaemin Lee, et al.
Published: (2018-01-01)

Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats
by: Pin-Ho Pan, et al.
Published: (2022-07-01)

Ethyl Rosmarinate Protects High Glucose-Induced Injury in Human Endothelial Cells
by: Yan-Hui Shen, et al.
Published: (2018-12-01)

Kaempferol Suppresses Carbon Tetrachloride-Induced Liver Damage in Rats via the MAPKs/NF-κB and AMPK/Nrf2 Signaling Pathways
by: Changyong Lee, et al.
Published: (2023-04-01)

Protective effect of free phenolics from Lycopus lucidus Turcz. root on carbon tetrachloride-induced liver injury in vivo and in vitro
by: Yue-Hong Lu, et al.
Published: (2018-07-01)

Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
by: Guoen Cai, et al.
Published: (2022-05-01)

Rosmarinic acid ameliorates renal ischemia reperfusion damage in rats
by: Majid Tavafi, et al.
Published: (2020-05-01)

Development of Ultradeformable Liposomes with Fatty Acids for Enhanced Dermal Rosmarinic Acid Delivery
by: Thirapit Subongkot, et al.
Published: (2021-03-01)

Hepatoprotective potentials of methanol extract of T. conophorum seeds of carbon tetrachloride induced liver damage in Wistar rats
by: Kelly Oriakhi, et al.
Published: (2018-10-01)

Rosmarinic acid monotherapy is better than the combination of rosmarinic acid and telmisartan in preventing podocyte detachment and inhibiting the progression of diabetic nephropathy in rats
by: Samsu N, et al.
Published: (2019-08-01)

Preventive effect of salmon sperm DNA on acute carbon tetrachloride‐induced liver injury in mice through Nrf2/ARE and mitochondrial apoptosis pathway
by: Xinyi Huang, et al.
Published: (2023-02-01)

Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway
by: Yang Yao, et al.
Published: (2022-08-01)

Rosmarinic Acid in Underground Parts of Different Mentha Species
by: Mergová M., et al.
Published: (2023-08-01)

Electrochemical Methods and (Bio) Sensors for Rosmarinic Acid Investigation
by: Iulia Gabriela David, et al.
Published: (2020-08-01)

Protective Effects of Rosmarinic Acid on Testicular Torsion-Detorsion in an Animal Model
by: Abbas Raisi, et al.
Published: (2022-10-01)

Hepatoprotective effect of Garcinia xanthochymus and Garcinia lanceifolia against carbon tetrachloride-induced hepatic damage in rat
by: Nabajyoti Gogoi, et al.
Published: (2023-08-01)

Application of Rosmarinic Acid with Its Derivatives in the Treatment of Microbial Pathogens
by: Ourdia-Nouara Kernou, et al.
Published: (2023-05-01)

Production of rosmarinic acid in hairy root cultures of Salvia reuterana
by: Reza Norouzi, et al.
Published: (2016-05-01)

Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation
by: Tina Blažević, et al.
Published: (2021-01-01)

Hepatoprotective effect of Balanites aegyptiaca (L.) Delile leaves against carbon tetrachloride-induced hepatic damage in rats
by: Elwaleed E. Ibrahim, et al.
Published: (2016-03-01)

Hepatoprotective Effect of Trigona spp. Bee Propolis against Carbon Tetrachloride-Induced Liver Injury in Rat
by: Rachel Amelia, et al.
Published: (2016-06-01)

Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis
by: Myungsuk Kim, et al.
Published: (2020-04-01)

The Effect of Rosmarinic Acid on Oxidant-Antioxidant Balance in Acetaminophen-Induced Hepatotoxicity in Male Rats
by: Nahid Azarmehr, et al.
Published: (2020-11-01)

Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3β and phosphorylated AKT expression levels
by: Jia-Rong Jheng, et al.
Published: (2022-08-01)

Cardioprotective Effects of Rosmarinic Acid on Isoproterenol-Induced Myocardial Infarction in Rats
by: Negisa Seyed Toutounchi, Arash Afrooziyan, Maryam Rameshrad, Aysa Rezabakhsh, Haleh Vaez, Sanaz Hamedeyazdan, Fatemeh Fathiazad, Alireza Garjani
Published: (2017-06-01)

Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity
by: Arnaud F. Kouam, et al.
Published: (2017-09-01)

Hepatoprotective activity of aerial parts of Otostegia persica against carbon tetrachloride-induced liver damage in rats
by: Mehdi Akbartabar Toori, et al.
Published: (2015-04-01)