The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances
A new paradigm shift for the treatment of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection would be timely due to a progressive increase in antibiotic resistance. Such a shift in the perspective of the <i>H. pylori</i> approach should include the preliminar...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4361 |
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| author | Francesca Celiberto Giuseppe Losurdo Maria Pricci Bruna Girardi Angela Marotti Alfredo Di Leo Enzo Ierardi |
| author_facet | Francesca Celiberto Giuseppe Losurdo Maria Pricci Bruna Girardi Angela Marotti Alfredo Di Leo Enzo Ierardi |
| author_sort | Francesca Celiberto |
| collection | DOAJ |
| description | A new paradigm shift for the treatment of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection would be timely due to a progressive increase in antibiotic resistance. Such a shift in the perspective of the <i>H. pylori</i> approach should include the preliminary assessment of antibiotic resistance. However, the availability of sensitivity tests is not widespread and the guidelines have always indicated empirical treatments without taking into account the need to make sensitivity tests accessible, i.e., the necessary starting point for improving results in different geographical areas. Currently, the traditional tools for this purpose (culture) are based on performing an invasive investigation (endoscopy) and often involve technical difficulties; thus, they were only confined to the settings where multiple attempts at eradication have failed. In contrast, genotypic resistance testing of fecal samples using molecular biology methods is much less invasive and more acceptable to patients. The purpose of this review is to update the state of the art of molecular fecal susceptibility testing for the management of this infection and to extensively discuss the potential benefits of their large-scale deployment, i.e., novel pharmacological opportunities. |
| first_indexed | 2024-03-11T07:23:46Z |
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| id | doaj.art-a2b7458b6e7a431090c88202a955a404 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:46Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a2b7458b6e7a431090c88202a955a4042023-11-17T07:47:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245436110.3390/ijms24054361The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic ResistancesFrancesca Celiberto0Giuseppe Losurdo1Maria Pricci2Bruna Girardi3Angela Marotti4Alfredo Di Leo5Enzo Ierardi6Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalyTHD SpA, 42015 Correggio, ItalyTHD SpA, 42015 Correggio, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalySection of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, ItalyA new paradigm shift for the treatment of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection would be timely due to a progressive increase in antibiotic resistance. Such a shift in the perspective of the <i>H. pylori</i> approach should include the preliminary assessment of antibiotic resistance. However, the availability of sensitivity tests is not widespread and the guidelines have always indicated empirical treatments without taking into account the need to make sensitivity tests accessible, i.e., the necessary starting point for improving results in different geographical areas. Currently, the traditional tools for this purpose (culture) are based on performing an invasive investigation (endoscopy) and often involve technical difficulties; thus, they were only confined to the settings where multiple attempts at eradication have failed. In contrast, genotypic resistance testing of fecal samples using molecular biology methods is much less invasive and more acceptable to patients. The purpose of this review is to update the state of the art of molecular fecal susceptibility testing for the management of this infection and to extensively discuss the potential benefits of their large-scale deployment, i.e., novel pharmacological opportunities.https://www.mdpi.com/1422-0067/24/5/4361<i>Helicobacter pylori</i>stoolsantibiotic resistancetherapyeradicationgenotypic resistance |
| spellingShingle | Francesca Celiberto Giuseppe Losurdo Maria Pricci Bruna Girardi Angela Marotti Alfredo Di Leo Enzo Ierardi The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances International Journal of Molecular Sciences <i>Helicobacter pylori</i> stools antibiotic resistance therapy eradication genotypic resistance |
| title | The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances |
| title_full | The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances |
| title_fullStr | The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances |
| title_full_unstemmed | The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances |
| title_short | The State of the Art of Molecular Fecal Investigations for <i>Helicobacter pylori</i> (<i>H. pylori</i>) Antibiotic Resistances |
| title_sort | state of the art of molecular fecal investigations for i helicobacter pylori i i h pylori i antibiotic resistances |
| topic | <i>Helicobacter pylori</i> stools antibiotic resistance therapy eradication genotypic resistance |
| url | https://www.mdpi.com/1422-0067/24/5/4361 |
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