Role of sex in immune response and epigenetic mechanisms
Abstract The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in X chromosome genes and Y chromosome...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Epigenetics & Chromatin |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13072-024-00525-x |
| _version_ | 1797276282336051200 |
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| author | Sombodhi Bhattacharya Debasmita Sadhukhan Radha Saraswathy |
| author_facet | Sombodhi Bhattacharya Debasmita Sadhukhan Radha Saraswathy |
| author_sort | Sombodhi Bhattacharya |
| collection | DOAJ |
| description | Abstract The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in X chromosome genes and Y chromosome regulatory genes create a sex-based variance in the immune response between males and females. This leads to differential susceptibility in immune-related disorders like infections, autoimmunity, and malignancies. Various naturally available immunomodulators are also available which target immune pathways containing X chromosome genes. |
| first_indexed | 2024-03-07T15:26:00Z |
| format | Article |
| id | doaj.art-a2b7655c558c4ab6a48bbee2481f22fe |
| institution | Directory Open Access Journal |
| issn | 1756-8935 |
| language | English |
| last_indexed | 2024-03-07T15:26:00Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj.art-a2b7655c558c4ab6a48bbee2481f22fe2024-03-05T16:43:37ZengBMCEpigenetics & Chromatin1756-89352024-01-0117111310.1186/s13072-024-00525-xRole of sex in immune response and epigenetic mechanismsSombodhi Bhattacharya0Debasmita Sadhukhan1Radha Saraswathy2Biomedical Genetics Research Lab, School of Biosciences and Technology, Vellore Institute of TechnologyDepartment of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of TechnologyBiomedical Genetics Research Lab, School of Biosciences and Technology, Vellore Institute of TechnologyAbstract The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in X chromosome genes and Y chromosome regulatory genes create a sex-based variance in the immune response between males and females. This leads to differential susceptibility in immune-related disorders like infections, autoimmunity, and malignancies. Various naturally available immunomodulators are also available which target immune pathways containing X chromosome genes.https://doi.org/10.1186/s13072-024-00525-xSex chromosomesImmune responsesEpigeneticsAutoimmunityCancers immunomodulators |
| spellingShingle | Sombodhi Bhattacharya Debasmita Sadhukhan Radha Saraswathy Role of sex in immune response and epigenetic mechanisms Epigenetics & Chromatin Sex chromosomes Immune responses Epigenetics Autoimmunity Cancers immunomodulators |
| title | Role of sex in immune response and epigenetic mechanisms |
| title_full | Role of sex in immune response and epigenetic mechanisms |
| title_fullStr | Role of sex in immune response and epigenetic mechanisms |
| title_full_unstemmed | Role of sex in immune response and epigenetic mechanisms |
| title_short | Role of sex in immune response and epigenetic mechanisms |
| title_sort | role of sex in immune response and epigenetic mechanisms |
| topic | Sex chromosomes Immune responses Epigenetics Autoimmunity Cancers immunomodulators |
| url | https://doi.org/10.1186/s13072-024-00525-x |
| work_keys_str_mv | AT sombodhibhattacharya roleofsexinimmuneresponseandepigeneticmechanisms AT debasmitasadhukhan roleofsexinimmuneresponseandepigeneticmechanisms AT radhasaraswathy roleofsexinimmuneresponseandepigeneticmechanisms |