Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells

Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells

Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP), also known as AKAP450, is a cytosolic scaffolding protein involved in the targeted positioning of multiple signaling molecules, which are critical for cellular functioning. Here, we show that CG-NAP is predominantly expres...

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Bibliographic Details
Main Authors: Seow Theng Ong, Madhavi Latha Somaraju Chalasani, M. H. U. Turabe Fazil, Praseetha Prasannan, Atish Kizhakeyil, Graham D. Wright, Dermot Kelleher, Navin Kumar Verma
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
T-cell migration
AKAP450
AKAP350
adaptor protein
centrosomal proteins
microtubules
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00397/full

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