Discovery of E3 Ligase Ligands for Target Protein Degradation

Discovery of E3 Ligase Ligands for Target Protein Degradation

Target protein degradation has emerged as a promising strategy for the discovery of novel therapeutics during the last decade. Proteolysis-targeting chimera (PROTAC) harnesses a cellular ubiquitin-dependent proteolysis system for the efficient degradation of a protein of interest. PROTAC consists of...

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Bibliographic Details
Main Authors: Jaeseok Lee, Youngjun Lee, Young Mee Jung, Ju Hyun Park, Hyuk Sang Yoo, Jongmin Park
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
target protein degradation
PROTAC
E3 ligase ligand
Online Access:https://www.mdpi.com/1420-3049/27/19/6515

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