Spatially distributed dendritic resonance selectively filters synaptic input.
An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-08-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC4140644?pdf=render |
| _version_ | 1818296424521007104 |
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| author | Jonathan Laudanski Benjamin Torben-Nielsen Idan Segev Shihab Shamma |
| author_facet | Jonathan Laudanski Benjamin Torben-Nielsen Idan Segev Shihab Shamma |
| author_sort | Jonathan Laudanski |
| collection | DOAJ |
| description | An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechanism exploits the resonance of the dendritic membranes to preferentially filter synaptic inputs based on their temporal rates. A widely held view is that a neuron has one resonant frequency and thus can pass through one rate. Here we demonstrate through mathematical analyses and numerical simulations that dendritic resonance is inevitably a spatially distributed property; and therefore the resonance frequency varies along the dendrites, and thus endows neurons with a powerful spatiotemporal selection mechanism that is sensitive both to the dendritic location and the temporal structure of the incoming synaptic inputs. |
| first_indexed | 2024-12-13T04:03:19Z |
| format | Article |
| id | doaj.art-a2b8e6aec2924b4c9f03d48e81d8a134 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-13T04:03:19Z |
| publishDate | 2014-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-a2b8e6aec2924b4c9f03d48e81d8a1342022-12-22T00:00:21ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582014-08-01108e100377510.1371/journal.pcbi.1003775Spatially distributed dendritic resonance selectively filters synaptic input.Jonathan LaudanskiBenjamin Torben-NielsenIdan SegevShihab ShammaAn important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechanism exploits the resonance of the dendritic membranes to preferentially filter synaptic inputs based on their temporal rates. A widely held view is that a neuron has one resonant frequency and thus can pass through one rate. Here we demonstrate through mathematical analyses and numerical simulations that dendritic resonance is inevitably a spatially distributed property; and therefore the resonance frequency varies along the dendrites, and thus endows neurons with a powerful spatiotemporal selection mechanism that is sensitive both to the dendritic location and the temporal structure of the incoming synaptic inputs.http://europepmc.org/articles/PMC4140644?pdf=render |
| spellingShingle | Jonathan Laudanski Benjamin Torben-Nielsen Idan Segev Shihab Shamma Spatially distributed dendritic resonance selectively filters synaptic input. PLoS Computational Biology |
| title | Spatially distributed dendritic resonance selectively filters synaptic input. |
| title_full | Spatially distributed dendritic resonance selectively filters synaptic input. |
| title_fullStr | Spatially distributed dendritic resonance selectively filters synaptic input. |
| title_full_unstemmed | Spatially distributed dendritic resonance selectively filters synaptic input. |
| title_short | Spatially distributed dendritic resonance selectively filters synaptic input. |
| title_sort | spatially distributed dendritic resonance selectively filters synaptic input |
| url | http://europepmc.org/articles/PMC4140644?pdf=render |
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