An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04771-y |
| _version_ | 1819195756077121536 |
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| author | Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi |
| author_facet | Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi |
| author_sort | Keiko Kawauchi |
| collection | DOAJ |
| description | Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation. |
| first_indexed | 2024-12-23T02:17:49Z |
| format | Article |
| id | doaj.art-a2b986b81e324fa785914b0394c35e22 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:17:49Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a2b986b81e324fa785914b0394c35e222022-12-21T18:03:37ZengNature PortfolioNature Communications2041-17232018-06-019111210.1038/s41467-018-04771-yAn anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplexKeiko Kawauchi0Wataru Sugimoto1Takatoshi Yasui2Kohei Murata3Katsuhiko Itoh4Kazuki Takagi5Takaaki Tsuruoka6Kensuke Akamatsu7Hisae Tateishi-Karimata8Naoki Sugimoto9Daisuke Miyoshi10Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityFrontier Institute for Biomolecular Engineering Research (FIBER), Konan UniversityFrontier Institute for Biomolecular Engineering Research (FIBER), Konan UniversityFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan UniversityHyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation.https://doi.org/10.1038/s41467-018-04771-y |
| spellingShingle | Keiko Kawauchi Wataru Sugimoto Takatoshi Yasui Kohei Murata Katsuhiko Itoh Kazuki Takagi Takaaki Tsuruoka Kensuke Akamatsu Hisae Tateishi-Karimata Naoki Sugimoto Daisuke Miyoshi An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex Nature Communications |
| title | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex |
| title_full | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex |
| title_fullStr | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex |
| title_full_unstemmed | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex |
| title_short | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex |
| title_sort | anionic phthalocyanine decreases nras expression by breaking down its rna g quadruplex |
| url | https://doi.org/10.1038/s41467-018-04771-y |
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