Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans

Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans

Activation of a cytoprotective cellular pathway known as the heat shock response (HSR) is a promising strategy for the treatment of Alzheimer’s disease and other neurodegenerative diseases. Geranylgeranylacetone (GGA) is a commonly used anti-ulcer drug in Japan that has been shown to activate the HS...

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Bibliographic Details
Main Authors: Isiah Mossiah, Sabrina M. Perez, Taylor R. Stanley, Michaela K. Foley, Karen S. Kim Guisbert, Eric Guisbert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging
Subjects:
geranylgeranylacetone
HSF1
heat shock response
Alzheimer’s disease
aging
longevity
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.846977/full

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